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Neonatal outcomes of twins according to birth order, presentation and mode of delivery: a systematic review and meta-analysis

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Please cite this paper as: Rossi A, Mullin P, Chmait R. Neonatal outcomes of twins according to birth order, presentation and mode of delivery: a systematic review and meta-analysis. BJOG 2011;118:523–532. Background 

The optimal mode of delivery for twins is undetermined. Objective 

To review literature regarding the neonatal outcomes following twin delivery. Data sources 

Searches were conducted in PubMed, Medline, Embase, Cochrane library and reference lists. Selection criteria 

Studies selection criteria were: both twins alive at labour, outcomes stratified for birth order, presentation, planned and actual delivery mode. Eighteen articles were included in the meta-analysis (39 571 twin sets). Data collection and analysis 

The Meta-analysis of Observational Studies in Epidemiology guidelines were followed. Interstudy heterogeneity (I2) was tested. A fixed model was generated whenever I2 < 25%. Pooled odds ratios (OR) with 95% CI were computed. Intergroup comparison was significant if 95% CI did not encompass 1. The first and second twins were indicated as Twin A (TA) and Twin B (TB), respectively. Main results 

Neonatal morbidity was lower in TA than TB (3.0 versus 4.6%; OR 0.53; 95% CI 0.39–0.70). TA experienced neonatal death less often than TB (0.3 versus 0.6%; OR 0.55; 95% CI 0.38–0.81). No differences were noted between vertex and non-vertex and attempted vaginal delivery versus planned caesarean section in either TA or TB. In TA, neonatal morbidity was lower after vaginal delivery (1.1%) than caesarean section (2.2%; OR 0.47; 95% CI 0.27–0.82). Neonatal death was not associated with actual delivery mode. In TB, morbidity following combined delivery (19.8%) was higher than after vaginal delivery (9.5%; OR 0.55; 95% CI 0.41–0.74) or caesarean section (9.8%; OR 0.47; 95% CI 0.43–0.53). When outcomes were stratified for both presentation and delivery mode, mortality rate was lower after vaginal delivery than caesarean section for both vertex and nonvertex TB. Author’s conclusion 

An attempt at vaginal delivery should be considered in twin pregnancies with vertex/vertex presentation.
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Keywords: Birth order; caesarean section; multiple pregnancies; twin delivery; twins

Document Type: Research Article

Affiliations: 1: Clinic of Obstetrics and Gynaecology, ‘San Giacomo’ Hospital, Monopoli, Bari, Italy 2: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Publication date: 2011-04-01

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