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Invasive procedures for fetal karyotyping: no cause of subsequent gestational hypertension or pre-eclampsia

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Abstract:

Please cite this paper as: Lindgren P, Cederholm M, Haglund B, Axelsson O. Invasive procedures for fetal karyotyping: no cause of subsequent gestational hypertension or pre-eclampsia. BJOG 2010;117:1422–1425.

The aim was to estimate the risk of maternal hypertensive complications following first- or second-trimester invasive diagnostic procedures, i.e. chorionic villus sampling (CVS) and amniocentesis (AC). Odds ratios (ORs) for gestational hypertension, mild pre-eclampsia or severe pre-eclampsia were calculated for women who underwent CVS (n = 1 984) or AC (n = 21 748) compared with non-exposed women (n = 47 854). No increase in the development of gestational hypertension, mild pre-eclampsia or severe pre-eclampsia was observed. The results do not support an association between invasive procedures for fetal karyotyping and subsequent gestational hypertension or pre-eclampsia.

Keywords: Amniocentesis; chorionic villus sampling; hypertension; pre-eclampsia; pregnancy

Document Type: Short Communication

DOI: http://dx.doi.org/10.1111/j.1471-0528.2010.02665.x

Affiliations: Department of Women’s and Children’s Health/Obstetrics and Gynaecology, Uppsala University, Uppsala, Sweden

Publication date: October 1, 2010

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