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Perinatal complications increase the risk of postpartum depression. The Generation R Study

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Please cite this paper as: Blom E, Jansen P, Verhulst F, Hofman A, Raat H, Jaddoe V, Coolman M, Steegers E, Tiemeier H. Perinatal complications increase the risk of postpartum depression. The Generation R Study. BJOG 2010;117:1390–1398. Objective 

To examine whether specific pregnancy and delivery complications are risk factors for postpartum depression. Design 

A prospective longitudinal study. Setting 

Rotterdam, the Netherlands. Population 

A cohort of 4941 pregnant women who enrolled in the Generation R Study. Methods 

Information on perinatal complications was obtained from the midwife and hospital registries or by questionnaire. Logistic regression analyses were used to calculate the risk of postpartum depression for the separate perinatal complications. Main outcome measures 

Postpartum psychiatric symptoms were assessed 2 months after delivery using the Edinburgh postnatal depression scale. Results 

Several perinatal complications were significantly associated with postpartum depression, namely: pre-eclampsia (adjusted OR, aOR 2.58, 95% CI 1.30–5.14), hospitalization during pregnancy (aOR 2.25, 95% CI 1.19–4.26), emergency caesarean section (aOR 1.53, 95% CI 1.02–2.31), suspicion of fetal distress (aOR 1.56, 95% CI 1.08–2.27), a medically indicated delivery provided by an obstetrician (aOR 2.43, 95% CI 1.56–3.78), and hospital admission of the baby (aOR 1.45, 95% CI 1.10–1.92). Unplanned pregnancy, thrombosis, meconium-stained amniotic fluid, and Apgar score were not associated with postpartum depression after adjustment for confounding factors, such as pre-existing psychopathological symptoms and sociodemographic characteristics. The risk of postpartum depression increased with the number of perinatal complications women experienced (P < 0.001). Conclusions 

We showed that several pregnancy and delivery complications present a risk for women’s mental health in the postpartum period. Obstetricians, midwives, general practitioners, and staff at baby well clinics should be aware that women who experienced perinatal complications—especially those with a number of perinatal complications—are at risk for developing postpartum depression.
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Keywords: Complications; delivery; depression; postpartum; pregnancy; risk factors

Document Type: Research Article

Affiliations: 1: Department of Child and Adolescent Psychiatry 2: Department of Epidemiology 3: Department of Public Health 4: Department of Obstetrics and Gynaecology, Division of Obstetrics and Perinatal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands

Publication date: 2010-10-01

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