Has publication of the results of the ORACLE Children Study changed practice in the UK?

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Abstract:

Please cite this paper as: Kenyon S, Pike K, Jones D, Brocklehurst P, Marlow N, Salt A, Taylor D. Has publication of the results of the ORACLE Children Study changed practice in the UK? BJOG 2010;117:1344–1349. Objective 

To investigate whether publication of the results of the ORACLE Children’s Study, a 7-year follow-up of the ORACLE trial, changed practice with regard to the routine prescription of antibiotics to women with preterm rupture of membranes or spontaneous preterm labour (intact membranes). Design 

A comparative questionnaire survey of clinical practice in November 2007 (before publication) and March 2009 (after publication). Population 

Lead obstetricians for labour wards of all maternity units in the UK. Methods 

Self-administered questionnaires requested information about the routine prescription of antibiotics to women with either preterm rupture of membranes or spontaneous preterm labour (intact membranes). Main outcome measures 

Change in practice for prescription of antibiotics. Results 

The response rate was 166/214 (78%) in 2007 and 158/209 (76%) in 2009. In total, 120 maternity units responded on both occasions. For women with preterm rupture of membranes, 162/214 (98%) in 2007 and 151/158 (96%) in 2009 maternity units reported that they prescribed antibiotics, with the majority using erythromycin (98%). For women with spontaneous preterm labour (intact membranes), 35/166 (21%) in 2007 and 25/158 (16%) in 2009 maternity units reported that they routinely prescribed antibiotics. The findings from units who responded on both occasions are similar. Conclusions 

There has been little change in the reported prescription of antibiotics to women with either preterm rupture of membranes or spontaneous preterm labour following publication of the ORACLE Children’s Study. This suggests that current practice may require updated guidance.

Keywords: Antibiotics for women with PROM or SPL; Change in Practice

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1471-0528.2010.02661.x

Affiliations: 1: School of Health and Population Sciences, University of Birmingham, Edgbaston, UK 2: Bristol Royal Infirmary, Bristol, UK 3: Health Sciences Department, University of Leicester, Leicester, UK 4: National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK 5: Institute of Women’s Health, University College Hospital, London, UK 6: Great Ormond Hospital for Sick Children and Institute of Child Health, University College Hospital, London, UK 7: Maternal and Newborn Health Initiative, International Federation of Gynaecology and Obstetrics, FIGO House, London, UK

Publication date: October 1, 2010

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