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A randomised controlled trial of low-dose misoprostol and dinoprostone vaginal pessaries for cervical priming

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Abstract:

Please cite this paper as: Tan T-C, Yan S, Chua T, Biswas A, Chong Y-S. A randomised controlled trial of low-dose misoprostol and dinoprostone vaginal pessaries for cervical priming. BJOG 2010;117:1270–1277. Objective 

We studied the efficacy of 25-μg misoprostol pessaries as either single or double dose compared with a 3-mg dinoprostone pessary for cervical priming. Design and setting 

A randomised controlled trial in Singapore. Population 

One hundred and seventy-one women with term pregnancies and modified Bishop scores (mBS) ≤6 from 2003 to 2004. Method 

Patients were randomised to single misoprostol dose, double misoprostol dose or the current dinoprostone regimen. Main outcome measures 

Primary outcome was number of women who achieved favourable mBS >6 or active labour by day 2. Secondary outcomes were time interval from insertion to delivery, cardiotocographic abnormalities, delivery and neonatal outcome. Results 

More women in the misoprostol double-dose group (96.6%) and dinoprostone group (93%) achieved the primary outcome compared with the single-dose group (77.8%) (P = 0.003 and P = 0.03, respectively). There was no difference in secondary outcomes. More multiparous women achieve primary outcome compared with nulliparous women (odds ratio 0.21, 95% confidence interval 0.06–0.77). Conclusion 

Double-dose misoprostol 25 μg is as effective as dinoprostone 3 mg inserts for cervical priming; both are more efficacious than a single-dose misoprostol pessary. Parity prognosticates the success of induction.

Keywords: Cervical priming; dinoprostone; low-dose misoprostol

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1471-0528.2010.02602.x

Affiliations: 1: Department of Obstetrics and Gynaecology, KK Women’s and Children’s Hospital 2: Biostatistics Section, Clinical Trials and Epidemiology Research Unit 3: Department of Obstetrics and Gynaecology, National University Hospital 4: Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital, Singapore, Singapore

Publication date: September 1, 2010

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