Recurrence risk of stillbirth in a second pregnancy

Authors: Bhattacharya, S¹; Prescott, GJ²; Black, M³; Shetty, A⁴

Source: BJOG: An International Journal of Obstetrics & Gynaecology, Volume 117, Number 10, September 2010 , pp. 1243-1247(5)

Publisher: Wiley-Blackwell

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Abstract:

Please cite this paper as: Bhattacharya S, Prescott G, Black M, Shetty A. Recurrence risk of stillbirth in a second pregnancy. BJOG 2010;117:1243-1247. Objective

To examine the risk of recurrence of stillbirth in a second pregnancy. Design

Retrospective cohort study. Setting

Scotland, UK. Population

All women who delivered their first and second pregnancies in Scotland between 1981 and 2005. Methods

All women delivering for the first time between 1981 and 2000 were linked to records of their second pregnancy using routinely collected data from the Scottish Morbidity Returns. Women who had an intrauterine death in their first pregnancy formed the exposed cohort, whereas those who had a live birth formed the unexposed cohort. Main outcome measure

Stillbirth in a second pregnancy. Results

After adjusting for confounding factors, the odds of recurrence of stillbirth in a second pregnancy were found to be 1.94 (99% CI 1.29-2.92) compared with women who had had a live birth in their first pregnancy. Other factors associated with recurrence of stillbirth in a second pregnancy included placental abruption (adjusted OR 1.96; 99% CI 1.60-2.41), preterm delivery (adjusted OR 7.45; 99% CI 5.91-9.39) and low birthweight (adjusted OR 6.69; 99% CI 5.31-8.42). A Bayesian analysis using minimally informative normal priors found the risk of recurrence of stillbirth in a second pregnancy to be 1.59 (99% CI 1.10-2.33). Conclusions

Women who have stillbirth in their first pregnancy have a higher risk of recurrence in their next pregnancy.

Keywords: Intrauterine death; recurrence; stillbirth

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1471-0528.2010.02641.x

Affiliations: 1: Dugald Baird Centre for Research on Women's Health, Aberdeen Maternity Hospital, Aberdeen, UK 2: Medical Statistics Team, Section of Population Health, University of Aberdeen, Aberdeen, UK 3: Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital, Aberdeen, UK 4: Department of Obstetrics, Aberdeen Maternity Hospital, Aberdeen, UK

Publication date: 2010-09-01

Recurrence risk of stillbirth in a second pregnancy

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