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Copper T380A intrauterine device for emergency contraception: a prospective, multicentre, cohort clinical trial

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Abstract:

Please cite this paper as: Wu S, Godfrey E, Wojdyla D, Dong J, Cong J, Wang C, von Hertzen H. Copper T380A intrauterine device for emergency contraception: a prospective, multicentre, cohort clinical trial. BJOG 2010;117:1205–1210. Objective 

To determine the effectiveness of the Copper T380A (CuT380A) intrauterine device (IUD) as an emergency contraceptive in women. Design 

Prospective, multicentre, cohort clinical trial. Setting 

Eighteen family planning clinics in China. Sample 

A cohort of 1963 women, aged 18–44 years, requesting emergency contraception within 120 hours of unprotected sexual intercourse. Methods 

Women requesting emergency contraception were followed at 1, 3 and 12 months after the insertion of CuT380A. Main outcome measures 

Efficacy of CuT380A as emergency contraception and for up to 12 months of postinsertion use. Insertion complication rates, reported side-effects and continuation rates at 12 months were also recorded. Results 

No pregnancies occurred prior to or at the first follow-up visit, making CuT380A 100% effective as emergency contraception in this study. The pregnancy rate over the 12-month period was 0.23 per 100 women. In all, 29 (1.5%) women experienced a difficult IUD insertion process, requiring local anaesthesia or prophylactic antibiotics. No uterine perforations occurred. The main side-effects were increased menstrual bleeding and menstrual disturbances. The 12-month postinsertion continuation rate was 94.0 per 100 woman-years. Conclusions 

CuT380A is a safe and effective method for emergency contraception. The advantages of CuT380A include its ability to provide effective, long-term contraception.

Keywords: Copper T380A; emergency contraception; intrauterine contraception; long-acting reversible contraception

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1471-0528.2010.02652.x

Affiliations: 1: National Research Institute for Family Planning, Beijing, China 2: Department of Family Medicine, University of Illinois College of Medicine, Chicago, IL, USA 3: Centro Rosarino de Estudios Perinatales (CREP), Rosario, Argentina 4: Qingdao Family Planning Research Institute, Qingdao, China 5: UNDP/UNPFA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Geneva, Switzerland

Publication date: 2010-09-01

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