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Association of interferon-γ +874A polymorphism with the risk of developing cervical cancer in north-Indian population

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Please cite this paper as: Gangwar R, Pandey S, Mittal R. Association of interferon-γ +874A polymorphism with the risk of developing cervical cancer in north-Indian population. BJOG 2009; DOI: 10.1111/j.1471-0528.2009.02307.x Objective 

Interferon gamma (IFN-γ) is a pro-inflammatory cytokine playing a pivotal role in both innate and adaptive immune responses. A single nucleotide polymorphism located in the first intron of the human IFN-γ gene can influence the secretion of cytokine. Therefore, we aimed to investigate the association of IFN-γ T/A gene polymorphism with the risk of cervical cancer. Design 

Case–control study. Setting 

Uttar Pradesh State in India. Sample 

Two hundred cases with histologically proven cancer of the cervix and healthy controls (n = 230), age and ethnicity matched were recruited in this study. Methods 

Genotyping was performed for bi-allelic +874 (T/A) polymorphism of IFN-γ by amplification refractory mutation system method. Main outcome measures 

Low producer IFN-γ +874 AA genotype was associated with high risk for cervical cancer, which further modulated the increased risk in tobacco users. Results 

IFN-γ AA genotype which is low producer of IFN-γ was associated with increased risk of cervical cancer (OR = 2.43, P = 0.003). Allele A was at 1.54-fold increased risk of cervical cancer (OR=1.54, P = 0.002). The AA genotype showed statistically significant risk with high stage (III + IV) of cervical cancer (OR = 4.99, P = 0.001). In tobacco users, AA genotype showed significantly increased susceptibility to cervical cancer (OR = 5.08, P = 0.010). Conclusion 

Variation in IFN-γ +874 AA genotype because of ethnicity in north-Indian population may represent an important susceptibility biomarker for cervical cancer risk as well as other diseases and should be explored further.

Keywords: Cervical cancer; IFN-γ; polymorphism; tobacco

Document Type: Research Article


Affiliations: 1: Department of Urology and Renal Transplantation 2: Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India

Publication date: November 1, 2009


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