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Increased serum phosphodiesterase activity in women with pre-eclampsia

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To measure the activity of serum phosphodiesterase (PDE) in pre-eclampsia. Design 

Case–control study. Setting 

Nephrology Laboratory and Obstetrics Unit at São Lucas Hospital from Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. Sample 

Twenty-nine normal and 28 pregnant women with pre-eclampsia. Methods 

Serum was collected from women with pre-eclampsia, at the time of diagnosis, and from gestation-matched controls. Circulating PDE activity was assessed by measuring consumption of the substrate thymidine 5′-monophosphate p-nitrophenyl ester and expressed as PDE units/l. Main outcome measures 

Serum PDE Activity. Results 

Mean substrate consumption was higher in pre-eclamptic condition (Vmax= 15.8 ± 1.4 versus 12.7 ± 0.9 U/L, P= 3.7 × 10−14). Conclusion 

These data suggest that altered PDE activity may play a role in pre-eclampsia endothelial dysfunction.

Keywords: Nitric oxide; phosphodiesterase; pre-eclampsia; pregnancy

Document Type: Research Article


Affiliations: Programa de Pós-graduação em Biologia Celular e Molecular, Centro de Biotecnologia do Rio Grande do Sul. Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

Publication date: 2006-05-01

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