Skip to main content

The changing role of progesterone in preterm labour

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Progesterone is an essential hormone in the process of reproduction. It is involved in the menstrual cycle, implantation and is essential for pregnancy maintenance. Although the pharmacokinetics and pharmacodynamics of progesterone have been well studied, and since 1935 it has been synthesised and is now available commercially, its use in the pathophysiology of pregnancy remains controversial. One of these concerns is the way in which the hormone is administered, with parenteral use proving the best way to obtain optimal plasma levels. Another concern is the paucity of randomised controlled trials and the different dosages and populations studied. As a result, the therapeutic application of progesterone in pregnancy is restricted to the prevention and treatment of threatened miscarriage, recurrent miscarriage and preterm birth. Progesterone is efficacious when continuation of pregnancy is hampered by immunological factors, luteinic and neuroendocrine deficiencies and myometrial hypercontractility. This may explain the reduction in the incidence of preterm birth in high risk pregnant women using high-dosage prophylactic progesterone.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1471-0528.2005.00586.x

Affiliations: 1: Centre of Reproductive and Perinatal Medicine, Department of Gynaecological, Obstetrical and Pediatric Sciences, University of Perugia, Italy 2: Department of Obstetrics and Gynecology, University of Belgrade, Serbia and Montenegro

Publication date: March 1, 2005

bsc/bjo/2005/00000112/A00101s1/art00012
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more