A randomised placebo-controlled trial to determine the effect of vitamin E in treatment of primary dysmenorrhoea

Authors: Ziaei, S.; Faghihzadeh, S.; Sohrabvand, F.; Lamyian, M.; Emamgholy, T.

Source: BJOG: An International Journal of Obstetrics & Gynaecology, Volume 108, Number 11, November 2003 , pp. 1181-1183(3)

Publisher: Wiley-Blackwell

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Abstract:

Objective

To determine whether vitamin E is effective in the treatment of primary dysmenorrhoea. Design

A randomised placebo-controlled trial. Participants

One hundred girls, aged 16-18 years old who suffered from primary dysmenorrhoea, among 1000 students attending a public high school in Region 5 in the Greater Tehran Municipality. Methods

Fifty girls were given 500 units of vitamin E (five tablets) per day, and 50 were given five placebo tablets per day. The treatment began two days before the beginning of menstruation and continued through the first three days of bleeding. The severity of pain before and after the treatment was studied. Treatment in both groups was carried out in two consecutive menstrual periods. Results

The severity of pain in the two groups was reduced after treatment, but the reduction was greater in the group treated with vitamin E. These differences were maintained in the second month of therapy. Conclusion

Both placebo and vitamin E are effective in relieving symptoms due to primary dysmenorrhoea, but the effects of vitamin E are more marked.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1471-0528.2003.00279.x

Publication date: 2003-11-01