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Meconium and fetal hypoxia: some experimental observations and clinical relevance

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Abstract:

In an experimental study, chemically sympathectomised near term fetal sheep and a control group were subjected to repeated episodes of acute hypoxia. Despite severe hypotension and metabolic acidosis, no animal in the control group had meconium-stained amniotic fluid, whereas every animal in the sympathectomised group had heavily meconium-stained amniotic fluid at the end of the experiments. These data and the available literature do not support a direct association between acute hypoxia and meconium-stained amniotic fluid but suggest that a reduction in sympathetic neural tone must be a component of meconium passage. Clinical and experimental data on the occurrence of meconium-stained amniotic fluid are reviewed.

Document Type: Short Communication

DOI: https://doi.org/10.1111/j.1471-0528.2002.01055.x

Affiliations: 1: Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand 2: Liggins Research Institute, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand

Publication date: 2002-10-01

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