Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: a systematic quantitative review

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Objective

To determine the accuracy of outpatient endometrial biopsy in diagnosing endometrial cancer in women with abnormal uterine bleeding. Design

A systematic quantitative review of published research. Methods

Studies were selected if accuracy of outpatient endometrial biopsy was estimated compared with a reference standard. Diagnostic accuracy was determined by pooled likelihood ratios for positive and negative test results. There were 1013 subjects in 13 diagnostic evaluations reported in 11 primary studies. Results

A positive test result on outpatient biopsy diagnosed endometrial cancer with a pooled likelihood ratio of 66.48 (95% CI 30.04–147.13) while a negative test result had a pooled likelihood ratio of 0.14 (95% CI 0.08–0.27). The post test probability of endometrial cancer was 81.7% (95% CI 59.7%–92.9%) for a positive test and 0.9% (95% CI 0.4%–2.4%) for a negative test. Conclusion

Outpatient endometrial biopsy has a high overall accuracy in diagnosing endometrial cancer when an adequate specimen is obtained. A positive test result is more accurate for ruling in disease than a negative test result is for ruling it out. Therefore, in cases of abnormal uterine bleeding where symptoms persist despite negative biopsy, further evaluation will be warranted.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1471-0528.2002.01088.x

Publication date: March 1, 2002

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more