Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: a systematic quantitative review
To determine the accuracy of outpatient endometrial biopsy in diagnosing endometrial cancer in women with abnormal uterine bleeding. Design
A systematic quantitative review of published research. Methods
Studies were selected if accuracy of outpatient endometrial biopsy was estimated compared with a reference standard. Diagnostic accuracy was determined by pooled likelihood ratios for positive and negative test results. There were 1013 subjects in 13 diagnostic evaluations reported in 11 primary studies. Results
A positive test result on outpatient biopsy diagnosed endometrial cancer with a pooled likelihood ratio of 66.48 (95% CI 30.04–147.13) while a negative test result had a pooled likelihood ratio of 0.14 (95% CI 0.08–0.27). The post test probability of endometrial cancer was 81.7% (95% CI 59.7%–92.9%) for a positive test and 0.9% (95% CI 0.4%–2.4%) for a negative test. Conclusion
Outpatient endometrial biopsy has a high overall accuracy in diagnosing endometrial cancer when an adequate specimen is obtained. A positive test result is more accurate for ruling in disease than a negative test result is for ruling it out. Therefore, in cases of abnormal uterine bleeding where symptoms persist despite negative biopsy, further evaluation will be warranted.
Document Type: Research Article
Publication date: March 1, 2002