Lack of association of soluble endothelial protein C receptor and PROCR 6936A/G polymorphism with the risk of venous thromboembolism in a prospective study
Prior case–control studies reported that levels of the soluble form of the endothelial protein C receptor (sEPCR) were strongly controlled by the PROCR 6963A/G polymorphism and higher levels were a risk factor for venous thromboembolism (VTE). We sought to prospectively examine the association of sEPCR and the 6963A/G polymorphism with the incidence of VTE. The Longitudinal Investigation of Thromboembolism Etiology (LITE) pooled data from the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk in Communities (ARIC) Study on men and women aged ≥45 years. A nested case–control study of 458 incident VTE and 1038 controls was performed. sEPCR levels were distributed trimodally according to 6963A/G polymorphism. Adjusting for age, sex and race, there was no overall association between sEPCR level and VTE: odds ratio (OR) [95% confidence interval] for highest versus lowest quartile = 1·17[0·86–1·59]. However, higher sEPCR was associated with VTE in non-whites (OR = 1·84[1·05–3·22]) and women (OR = 1·51[1·01–2·26]). The 6963A/G polymorphism was not associated with VTE risk (OR = 0·93[0·70–1·25]). In conclusion, sEPCR levels and the PROCR 6963A/G polymorphism were not associated overall with increased risk of VTE.
Document Type: Research Article
Affiliations: 1: Department of Medicine, University of Vermont and Fletcher Allen Health Care, Bington, VT 2: Department of Epidemiology, University of Washington, Seattle, WA 3: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA 4: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
Publication date: April 1, 2009