Predicting clinical severity in sickle cell anaemia

Author: Steinberg, M. H.

Source: British Journal of Haematology, Volume 129, Number 4, May 2005 , pp. 465-481(17)

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Abstract:

Summary

The ability to predict the phenotype of an individual with sickle cell anaemia would allow a reliable prognosis and could guide therapeutic decision making. Some risk factors for individual disease complications are known but are insufficiently precise to use for prognostic purposes; predicting the global disease severity is not yet possible. Genetic association studies, which attempt to link gene polymorphisms with selected disease subphenotypes, may eventually provide useful methods of foretelling the likelihood of certain complications and allow better individualized treatment.

Keywords: single nucleotide polymorphisms; linkage disequilibrium; genetic association; fetal haemoglobin; sickle cell

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2141.2005.05411.x

Publication date: 2005-05-01