Authors: Alvarez-Larrán A.¹; García-Pagán J.C.²; Abraldes J.G.²; Arellano E.¹; Reverter J.C.³; Bosch J.²; Cervantes F.¹

Source: British Journal of Haematology, Volume 124, Number 3, February 2004 , pp. 329-335(7)

Publisher: Wiley-Blackwell

Abstract:

Summary

Budd–Chiari syndrome and portal vein thrombosis (BCS/PVT) are frequently associated with polycythaemia vera (PV). In an attempt to elucidate the mechanisms of BCS/PVT secondary to PV (T-PV), CD11b neutrophil expression, neutrophil oxidative burst and platelet–neutrophil complexes (PNC) were assessed in 17 such patients. Three groups served as controls: BCS/PVT not secondary to PV (T-nPV; n = 20), PV without thrombosis (PV-nT; n = 16), and healthy controls (HC; n = 20). Baseline CD11b expression (in mean fluorescence intensity units) was 101 [95% confidence interval (CI): 79–128] in T-PV patients, versus 25 (95% CI: 18–35) in T-nPV, 59 (95% CI: 43–80) in PV-nT, and 34 (95% CI: 25–48) in HC (P < 0·001). After N-formyl-L-methionyl-L-leucyl-L-phenylalanine activation, T-PV patients also showed higher CD11b values: 190 (95% CI: 151–238), versus 55 (95% CI: 41–72) in T-nPV, 111 (95% CI: 81–153) in PV-nT, and 77 (95% CI: 63–95) in HC (P < 0·001). In BCS/PVT, CD11b neutrophil expression had 90% specificity and 100% sensitivity for the association with PV. Finally, PV patients had higher oxidative burst and PNC than T-nPV patients or HC (P < 0·05). These results support a role for neutrophils in BCS/PVT secondary to PV and indicate that neutrophil CD11b expression could be of use for PV screening in BCS/PVT patients.

Keywords: Budd–Chiari syndrome; abdominal vein thrombosis; polycythaemia vera; thrombosis; neutrophils

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1365-2141.2003.04770.x

Affiliations: 1: Haematology Department, Institute of Haematology and Oncology 2: Hepatic Haemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives 3: Haemotherapy and Haemostasis Department, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain

Publication date: 2004-02-01

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