Use of oral glycopyrronium bromide in hyperhidrosis
Authors: Bajaj, V.; Langtry, J.A.A.
Source: British Journal of Dermatology, Volume 157, Number 1, July 2007 , pp. 118-121(4)
Idiopathic hyperhidrosis may be a disabling condition causing emotional stress and negative impact on a patient's quality of life. Oral anticholinergics are one of the treatments available. There are few published data on the use of the anticholinergic drug glycopyrronium bromide (glycopyrrolate) given orally in the treatment of hyperhidrosis. Objectives
To report a retrospective analysis describing the treatment responses, doses and side-effects of oral glycopyrrolate in the treatment of idiopathic hyperhidrosis. Methods
Review of case notes in a series of 24 patients, nine with generalized and 15 with localized hyperhidrosis. Results
Fifteen of 19 evaluable patients (79%) responded to oral glycopyrrolate. However, treatment was limited by side-effects in around one third of patients. Conclusions
A prospective clinical study to compare the efficacy and side-effects of oral anticholinergics is warranted.
Document Type: Research Article
Affiliations: Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, U.K.
Publication date: July 1, 2007