Use of oral glycopyrronium bromide in hyperhidrosis

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Abstract:

Summary Background 

Idiopathic hyperhidrosis may be a disabling condition causing emotional stress and negative impact on a patient's quality of life. Oral anticholinergics are one of the treatments available. There are few published data on the use of the anticholinergic drug glycopyrronium bromide (glycopyrrolate) given orally in the treatment of hyperhidrosis. Objectives 

To report a retrospective analysis describing the treatment responses, doses and side-effects of oral glycopyrrolate in the treatment of idiopathic hyperhidrosis. Methods 

Review of case notes in a series of 24 patients, nine with generalized and 15 with localized hyperhidrosis. Results 

Fifteen of 19 evaluable patients (79%) responded to oral glycopyrrolate. However, treatment was limited by side-effects in around one third of patients. Conclusions 

A prospective clinical study to compare the efficacy and side-effects of oral anticholinergics is warranted.

Keywords: glycopyrronium bromide; hyperhidrosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-2133.2007.07884.x

Affiliations: Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, U.K.

Publication date: July 1, 2007

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