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Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial

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Summary Background 

Photodynamic therapy (PDT) of actinic keratosis (AK) using methylaminolaevulinate (MAL) is an effective and safe treatment option, but the procedure is painful. Objectives 

To evaluate the efficacy and pain associated with variable pulsed light (VPL), a prospective, randomized, controlled split-face study was performed. Methods 

Topical MAL-PDT was conducted in 25 patients with AK (n = 238) who were suitable for two-sided comparison. After incubation with MAL, irradiation was performed with a light-emitting diode (LED) (50 mW cm−2; 37 J cm−2) vs. VPL (80 J cm−2, double pulsed at 40 J cm−2, pulse train of 15 impulses each with a duration of 5 ms, 610–950 nm filtered hand piece) followed by re-evaluation up to 3 months. Results 

The pain during and after therapy was significantly lower with VPL irradiation [t (d.f. = 24) = 4·42, P < 0·001]. The overall mean ± SD infiltration and keratosis score at 3 months after treatment was 0·86 ± 0·71 (LED system) vs. 1·05 ± 0·74 (VPL device) (no statistically significant difference; P = 0·292). Patient satisfaction following both treatment modalities did not significantly differ at the 3-month follow up (P = 0·425). Conclusions 

VPL used for MAL-PDT is an efficient alternative for the treatment of AK that results in complete remission and cosmesis equivalent to LED irradiation but causes significantly less pain.

Keywords: 5-aminolaevulinic acid; actinic keratosis; photodynamic therapy; protoporphyrin IX; randomized controlled trial

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-2133.2007.07959.x

Affiliations: 1: Department of Special and Environmental Dermatology, Medical University of Vienna, 1090 Vienna, Austria 2: Centre of Clinical Studies, University of Regensburg, 93042 Regensburg, Germany

Publication date: July 1, 2007

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