Mucocutaneous bullous amyloidosis with an unusual mixed protein composition of amyloid deposits
We describe a case of fatal systemic amyloidosis presenting with mucocutaneous bullous lesions in a patient with IgA κ monoclonal gammopathy. The amyloid plaques were composed of an unusual mixture of immunoglobulin κ light chain and amyloid A proteins. Whereas oesophageal and oropharyngeal blisters are known to occur in several types of bullous dermatoses, to our knowledge this is the first report of oesophagopharyngeal blisters complicating bullous amyloidosis.
Document Type: Research Article
Affiliations: Division of Dermatopathology, Department of Dermatology, The Johns Hopkins Medical Institutions, Baltimore, MD, 21287, U.S.A.
Publication date: April 1, 2006