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Panniculitis secondary to extravasation of clarithromycin in a patient with α1-antitrypsin deficiency (phenotype PiZ)

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Summary 

α1-Antitrypsin deficiency (AATD) is known to be associated with panniculitis. Although reports of this association are rare, the true incidence may be unappreciated because of underdiagnosis of AATD. We report a case of panniculitis occurring in a 34-year-old woman with severe AATD following the extravasation of clarithromycin infused intravenously for treatment of community-acquired pneumonia. Resolution occurred with conservative management. The histopathology and management of this unusual condition are discussed, with a review of the literature.
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Keywords: emphysema; panniculitis; α1-antitrypsin deficiency

Document Type: Research Article

Affiliations: 1: Departments of Pulmonology, 2: Dermatology and 3: Pathology, University Hospital Birmingham, Birmingham, U.K.

Publication date: 01 August 2003

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