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Panniculitis secondary to extravasation of clarithromycin in a patient with α1-antitrypsin deficiency (phenotype PiZ)

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Abstract:

Summary 

α1-Antitrypsin deficiency (AATD) is known to be associated with panniculitis. Although reports of this association are rare, the true incidence may be unappreciated because of underdiagnosis of AATD. We report a case of panniculitis occurring in a 34-year-old woman with severe AATD following the extravasation of clarithromycin infused intravenously for treatment of community-acquired pneumonia. Resolution occurred with conservative management. The histopathology and management of this unusual condition are discussed, with a review of the literature.

Keywords: emphysema; panniculitis; α1-antitrypsin deficiency

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1365-2133.2003.05530.x

Affiliations: 1: Departments of Pulmonology, 2: Dermatology and 3: Pathology, University Hospital Birmingham, Birmingham, U.K.

Publication date: August 1, 2003

bsc/bjd/2003/00000149/00000002/art00029
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