Subcutaneous nodules on the buttocks as a manifestation of dialysis-related amyloidosis: a clinicopathological entity?

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While β2-microglobulin amyloidosis occurring in patients undergoing long-term dialysis is frequently associated with joint involvement, skin lesions have rarely been encountered. We report a 57-year-old man with extensive subcutaneous amyloid deposition forming large nodules on the buttocks; the patient had been on maintenance dialysis for 28 years. Although this condition is rare, a review of the literature indicates that the majority of such lesions occur around the buttock region.

Keywords: electron microscopy; long-term dialysis; β2-microglobulin

Document Type: Research Article


Affiliations: 1: Department of Dermatology, Sapporo City General Hospital, North 11, West 13, Chuo-Ku, Sapporo 060–8604, Japan 2: Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

Publication date: August 1, 2003

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