Severe digital necrosis in an elderly patient with heterozygous factor V Leiden mutation

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We report an 81-year-old female with a heterozygous factor V Leiden mutation who developed purpura fulminans. Digital necrosis, a characteristic clinical feature of purpura fulminans was prominent. Purpura fulminans is more common in children and adult cases are rare. Of eight reported cases of purpura fulminans resulting from a heterozygous factor V Leiden mutation recorded in the literature, only two were in adults: 40 and 42 years of age, respectively. This is the first report of this condition arising in a patient in her eighties.

Keywords: digital necrosis; factor V Leiden; protein C; purpura fulminans

Document Type: Research Article


Affiliations: 1: Haematology and 2: Pathology, Royal Gwent Hospital, Cardiff Road, Newport NP9 2UB, U.K. 3: Departments of Dermatology,

Publication date: December 1, 2000

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