Renal failure and cholestatic jaundice as unusual complications of childhood pustular psoriasis
Abstract:Generalized pustular psoriasis (GPP) is uncommon in children, and serious renal and liver complications arising from GPP are rarely reported. We describe a Chinese boy who had suffered from recurrent exacerbations of GPP from the age of 1 year. He developed IgA nephropathy at the age of 9 years. He also had recurrent episodes of oliguric renal failure, hepatomegaly and cholestasis associated with severe exacerbations of GPP. These complications progressed despite early antibiotics and supportive therapy, but responded promptly to intravenous methylprednisolone therapy. Ultimately, acitretin was given and he has successfully been in remission for a year.
Document Type: Research Article
Affiliations: 1: Departments of Paediatrics and 2: Social Hygiene Service, Department of Health, Government of Hong Kong SAR, Hong Kong SAR, China 3: Pathology, Tuen Mun Hospital, Tsing Chung Koon Road, Tuen Mun, Hong Kong SAR, China
Publication date: December 1, 2000