Skip to main content

Routine double treatments of superficial basal cell carcinomas using aminolaevulinic acid-based photodynamic therapy

Buy Article:

$51.00 plus tax (Refund Policy)


Background Superficial basal cell carcinomas of the skin (sBCC) often respond poorly to single-treatment aminolaevulinic acid-based photodynamic therapy (ALA–PDT), with a number of reports indicating a relapse rate of 50% or more.

Objectives To determine whether a second treatment at seven days can improve the response.

Methods Twenty-six lesions were treated twice with ALA–PDT, with an interval of 7 days between the two treatment sessions.

Results We observed a complete response rate of 100% 1 month after treatment. Only one lesion relapsed (16 months post-PDT), a relapse rate of 4% (median follow up 27 months; range 15–45 months). Cosmetic results were excellent.

Conclusions We consider routine double treatments with ALA–PDT to be an effective approach to the management of sBCC, particularly those located in anatomically difficult, or cosmetically sensitive, sites.

Keywords: ALA; BCC; PDT; open study; photodynamic; skin

Document Type: Research Article


Affiliations: 1: School of Medicine, 2: Cookridge Hospital, Leeds LS16 6QB, U.K. 3: Department of Colour Chemistry, Schools of 4: Paterson Institute for Cancer Research, Manchester M20 9BX, U.K. 5: Biomedical Sciences, and 6: Biochemistry and Molecular Biology, University of Leeds, LS2 9JT, U.K.

Publication date: December 1, 2000


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more