HLA-C and guttate psoriasis
Objectives We set out to determine whether further clinical subdivision of psoriasis is associated with tighter correlation with HLA-C alleles.
Patients/methods We determined the HLA-C locus genotype of 29 caucasian patients with guttate psoriasis presenting consecutively with guttate psoriasis associated with a history of a sore throat and/or an antistreptolysin O titre > 200 IU mL−1. Polymerase chain reaction typing using sequence-specific primers was used to detect all known HLA-C alleles. These data were compared with a control population of 604 random caucasian cadaver donors.
Results All patients (100%) with guttate psoriasis carried the Cw*0602 allele compared with 20% of the control population (odds ratio = ∞; 95% confidence limits 25·00–∞; Pcorrected < 0·0000002).
Conclusions This result is consistent with HLA-Cw*0602 playing a part directly in the pathogenesis of guttate psoriasis.
Document Type: Research Article
Affiliations: 1: Dermatology, 2: Tissue Typing Laboratory, Churchill Hospital, Oxford, Departments of 3: Immunology, 4: Skin Treatment and Research Laboratory, Chelsea & Westminster Hospital, Imperial College School of Medicine, London, U.K. 5: Public Health,
Publication date: 2000-12-01