Malignant melanoma and lymphoproliferative malignancy: is there a shared aetiology?

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Abstract:

We report seven patients who developed malignant melanoma either coincident with or before the diagnosis of non-Hodgkin’s lymphoma or chronic lymphatic leukaemia. One patient died secondary to leukaemia, and chemotherapy-induced immunosuppression may have contributed to the development of metastatic melanoma in another patient. Immunosuppression, exposure to ultraviolet radiation and genetic factors may result in a host environment that is conducive to the development of both tumours in these patients.

Keywords: chronic lymphatic leukaemia; immunosuppression; malignant melanoma; non-Hodgkin’s lymphoma; p16 gene; ultraviolet radiation

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1365-2133.2000.03610.x

Affiliations: 1: Departments of Dermatology and 2: Histopathology, Royal Infirmary of Edinburgh, Lauriston Building, Edinburgh EH3 9YW, U.K.

Publication date: July 1, 2000

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