British Journal of Clinical Pharmacology

Looking back: editors' pick of 2008
pp. 1-4(4)
Authors: Loke, YK; Somogyi, A; Lewis, LD; Schachter, M; Cohen, AF; Ritter, JM

Biomarkers for the effects of cannabis and THC in healthy volunteers
pp. 5-21(17)
Authors: Zuurman, Lineke; Ippel, Annelies E.; Moin, Eduard; van Gerven, Joop M. A.

Effect of naproxen on the hypothalamic-pituitary- adrenal axis in healthy volunteers
pp. 22-28(7)
Authors: Eijsbouts, Agnes M. M.; Kempers, Marlies J. E.; Kramer, Renske S. A.; Hopman, Maria T. E.; van den Hoogen, Frank H. J.; Laan, Ronald F. J. M.; Hermus, Ad R. M. M.; Sweep, Fred C. G. J.; van de Putte, Leo B. A.

Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment
pp. 29-37(9)
Authors: Shiran, Mohammad-Reza; Lennard, Martin S.; Iqbal, Mohammad-Zafar; Lagundoye, Oldwale; Seivewright, Nicholas; Tucker, Geoffrey T.; Rostami-Hodjegan, Amin

4β-Hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin
pp. 38-43(6)
Authors: Diczfalusy, Ulf; Kanebratt, Kajsa P.; Bredberg, Eva; Andersson, Tommy B.; Böttiger, Ylva; Bertilsson, Leif

Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy
pp. 44-49(6)
Authors: Suzuki, Kunihiro; Doki, Kosuke; Homma, Masato; Tamaki, Hirofumi; Hori, Satoko; Ohtani, Hisakazu; Sawada, Yasufumi; Kohda, Yukinao

Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa
pp. 50-60(11)
Authors: Ekhart, Corine; Doodeman, Valerie D.; Rodenhuis, Sjoerd; Smits, Paul H. M.; Beijnen, Jos H.; Huitema, Alwin D. R.

A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers
pp. 61-67(7)
Authors: Becker, Matthijs L.; Visser, Loes E.; Newton-Cheh, Christopher; Hofman, Albert; Uitterlinden, André G.; Witteman, Jacqueline C. M.; Stricker, Bruno H. Ch.

The effects of melatonin on sleep-wake rhythm of daytime haemodialysis patients: a randomized, placebo-controlled, cross-over study (EMSCAP study)
pp. 68-75(8)
Authors: Koch, Birgit C. P.; Nagtegaal, J. Elsbeth; Hagen, E. Chris; van der Westerlaken, Monique M. L.; Boringa, Jan B. S.; Kerkhof, Gerard A.; Ter Wee, Piet M.

Relationship between HIV protease inhibitors and QTc interval duration in HIV-infected patients: a cross-sectional study
pp. 76-82(7)
Authors: Charbit, Beny; Rosier, Arnaud; Bollens, Diane; Boccara, Franck; Boelle, Pierre-Yves; Koubaa, Afef; Girard, Pierre-Marie; Funck-Brentano, Christian

Variability in the quality of overdose advice in Summary of Product Characteristics (SPC) documents: gut decontamination recommendations for CNS drugs
pp. 83-87(5)
Authors: Wall, Andrew J. B.; Bateman, D. N.; Waring, W. S.

Exposure to antibacterial agents with QT liability in 14 European countries: trends over an 8-year period
pp. 88-98(11)
Authors: Raschi, Emanuel; Poluzzi, Elisabetta; Zuliani, Chiara; Muller, Arno; Goossens, Herman; De Ponti, Fabrizio

Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials
pp. 99-109(11)
Authors: Smeeth, Liam; Douglas, Ian; Hall, Andrew J.; Hubbard, Richard; Evans, Stephen

High-dose antipsychotic use in schizophrenia: a comparison between the 2001 and 2004 Research on East Asia Psychotropic Prescription (REAP) studies
pp. 110-117(8)
Authors: Sim, Kang; Su, Hsin Chuan; Fujii, Senta; Yang, Shu-yu; Chong, Mian-Yoon; Ungvari, Gabor; Si, Tianmei; He, Yan Ling; Chung, Eun Kee; Chan, Yiong Huak; Shinfuku, Naotaka; Kua, Ee Heok; Tan, Chay Hoon; Sartorius, Norman

The CADEUS study: burden of nonsteroidal anti-inflammatory drug (NSAID) utilization for musculoskeletal disorders in blue collar workers
pp. 118-124(7)
Authors: Rossignol, Michel; Abouelfath, Abdelilah; Lassalle, Regis; Merlière, Yvon; Droz, Cécile; Bégaud, Bernard; Depont, Fanny; Moride, Yola; Blin, Patrick; Moore, Nicholas; Fourrier-Réglat, Annie

Randomized clinical comparisons of diclofenac concentration in the soft tissues and blood plasma between topical and oral applications
pp. 125-129(5)
Authors: Miyatake, Shin; Ichiyama, Hiroki; Kondo, Eiji; Yasuda, Kazunori

Do thiazide diuretics alter the pharmacokinetics of metformin in patients with type 2 diabetes already established on metformin?
pp. 130-131(2)
Authors: Sung, Eileen Y. Y.; Moore, Michael Peter; Lunt, Helen; Doogue, Matthew; Zhang, Mei; Begg, Evan J.

Pharmacokinetics, a main actor in a many-sided approach to severe 5-FU toxicity prediction
pp. 132-134(3)
Authors: Bocci, Guido; Di Paolo, Antonello; Barbara, Cecilia; Masi, Gianluca; Fornaro, Lorenzo; Loupakis, Fotios; Allegrini, Giacomo; Falcone, Alfredo; Del Tacca, Mario; Danesi, Romano

Mirtazapine induced nightmares in an adult male
pp. 135-136(2)
Authors: Dang, Amit; Garg, Gaurav; Rataboli, Padmanabh V.

Suggestions for effective contraception in isotretinoin therapy
pp. 137-138(2)
Authors: Kanelleas, Antonios I.; Thornton, Steve; Berth-Jones, John

Biphasic creatine kinase elevation in pseudoephedrine overdosage
pp. 139-140(2)
Authors: Gülhan, Bora; Bayrakcı, Benan; Babaoğlu, Melih Önder; Bal, Burak; Beken, Serdar

Investigator-initiated pragmatic trials in developing countries - much needed but much ignored
pp. 141-142(2)
Authors: Shafiq, Nusrat; Pandhi, Promila; Malhotra, Samir

Translation Section
pp. 143-150(8)