Profound weight loss associated with reboxetine use in a 44-year-old woman

Authors: Lu, T. Y.-T.¹; Kupa, A.²; Easterbrook, G.³; Mangoni, A. A.

Source: British Journal of Clinical Pharmacology, Volume 60, Number 2, August 2005 , pp. 218-220(3)

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Abstract:

We report a case of significant weight loss experienced by a 44-year-old Caucasian woman treated with reboxetine. She was treated with this drug at 12 mg daily for a total duration of 11 months. During the corresponding period her body mass index (BMI) decreased from a baseline of 21.4 kg m^-2 to a low of 16.8 kg m^-2. Withdrawal of the drug led to a full recovery of her BMI. The strongest evidence linking reboxetine to this woman's weight loss laid in the fact that the re-introduction of the drug subsequently caused a similar negative impact in her BMI.

Keywords: Reboxetine; weight loss; adverse drug reactions

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2125.2005.02407.x

Affiliations: 1: Clinical Pharmacology & Centre for Neuroscience, 2: Immunology, and 3: Pharmacy, Flinders Medical Centre and Flinders University, Adelaide, Australia

Publication date: 2005-08-01