Authors: Pitsiu M.¹; Hussein Z.; Majid O.¹; Aarons L.²; de Longueville M.³; Stockis A.³

Source: British Journal of Clinical Pharmacology, Volume 57, Number 4, April 2004 , pp. 402-411(10)

Publisher: Wiley-Blackwell

Abstract:

Aims

To evaluate retrospectively the population pharmacokinetics of cetirizine, a second-generation antihistamine, in children. Methods

Data were pooled from six clinical trials, in which cetirizine was administered orally in various formulations and in single and multiple dosage regimens. The population consisted of 112 children (33 female and 79 male) aged 6 months to 12 years. A one-compartment open model with first-order absorption and elimination was fitted to the plasma concentration-time profiles using nonlinear mixed effects modelling with first-order estimation. Results

A linear association was found between apparent clearance (CL/F) and age with the former increasing by 0.12 l h^-1 per year. The intercept of the relationship was slightly lower for female children (0.59 vs. 0.77 l h^-1 in male). The population estimate of CL/F for an average age of 7 years was 1.61 and 1.43 l h^-1 for male and female children, respectively. A linear association was found between apparent volume of distribution (V/F) and age with the former increasing by 1.4 l year^-1, with an intercept of 4.0 l. The population estimate of V/F for an average age of 7 years was 13.9 l. The magnitudes of interpatient variability were 35.6% for CL/F and 19.7% for V/F. The magnitude of residual variability in cetirizine concentrations was 26.9%. Conclusions

Population  analysis  predicts  a  linear  increase  in  cetirizine  CL/F  and V/F with age, with CL/F being slightly lower in female children, relative to males of the same age. However, this gender difference probably has no clinical consequences. Since V/F increased more rapidly with age than CL/F, a nonlinear increase in half-life was seen, from < 4 h in infants to near the adult value at 12 years of age. The current recommended dosing regimens that younger children should receive lower but more frequent doses, are confirmed by the present analysis.

Keywords: antihistamine; cetirizine; paediatric population pharmacokinetics

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1365-2125.2003.02017.x

Affiliations: 1: Medeval Ltd, Manchester, UK, 2: University of Manchester, Manchester, UK, and 3: UCB S.A. Pharma Sector, Belgium

Publication date: 2004-04-01

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