Authors: Parnell M.M.; Chin-Dusting J.P.F.; Starr J.; Kaye D.M.

Source: British Journal of Clinical Pharmacology, Volume 55, Number 2, February 2003 , pp. 212-215(4)

Publisher: Wiley-Blackwell

Abstract:

Aims

As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men. Method and results

Eleven physically active, HC males were recruited. Endothelial function [forearm blood flow response to brachial artery infusion of acetylcholine (Ach)] was assessed twice in each subject following atorvastatin or no therapy in a randomized crossover design. In addition, endothelial function was compared with an active, normolipidaemic control group (C). Atorvastatin therapy reduced total and LDL cholesterol, but had no effect on basal blood flow or endothelial function (peak ACh mean difference ± standard error 0.75 ± 1.75 ml min^-1 per 100 ml tissue) [95% confidence interval (CI) -3.1, 4.6]. In addition, there was no difference in endothelial function between the HC and C groups (-1.14 ± 2.60 ml min^-1 per 100 ml tissue; CI -6.53, 4.25). Conclusion

Statin therapy in HC patients with normal endothelial function does not augment endothelial function.

Keywords: blood flow; endothelium; hypercholesterolaemia; nitric oxide

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1365-2125.2003.t01-1-01752.x

Affiliations: 1: Alfred Baker Medical Unit and Wynn Department of Medical Cardiology, Baker Medical Research Institute, Melbourne, Australia

Publication date: 2003-02-01

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