Authors: Fourrier, Annie¹; Gasquet, Isabelle²; Allicar, Marie Pierre³; Bouhassira, Myriam³; Lépine, Jean Pierre⁴; Bégaud, Bernard¹

Source: British Journal of Clinical Pharmacology, Volume 49, Number 1, January 2000 , pp. 80-86(7)

Publisher: Wiley-Blackwell

Abstract:

Aims To describe the psychiatric indications of neuroleptics (especially the relative share of schizophrenic and other psychotic disorders) and the usage patterns of these drugs (dose, duration, coprescriptions).

Methods A one-day national cross-sectional survey in a random sample of 723 French psychiatrists was carried out in 1996. Each psychiatrist was asked to complete a standardized questionnaire for the first three patients seen the day of the survey to whom at least one neuroleptic was prescribed (initiated or renewed).

Results One thousand seven hundred and fifty-four questionnaires were returned. Three quarters of the patients (74%) were psychotic (664 with schizophrenia, and 636 other psychosis), 19.3% were depressive and 6.7% had other psychiatric disorders. Phenothiazines were the most often prescribed (40.8%), followed by butyrophenones (22.5%), benzamides (15.8%), other neuroleptics (14.8%) and thioxanthenes (6.1%). Among schizophrenic subjects, an average number of 1.54 (95% CI: 1.50-1.60) neuroleptics were prescribed per patient, compared with 1.4 (95% CI: 1.32-1.41) and 1.2 (95% CI: 1.14-1.23) in other psychotic and depressive subjects, respectively. Regardless of the indication, non-neuroleptic psychotropic drugs were coprescribed in 75.4%, mainly benzodiazepines (75.7%). Adjuvant drugs used in prevention or treatment of side-effects were coprescribed in 46.7%, mostly anticholinergic antiparkinsonians (86.1%).

Conclusions Neuroleptics are mainly prescribed for psychotic disorders and especially schizophrenia. However, current recommendations are not always followed.

Keywords: antipsychotic drugs; cross-sectional study; drug utilization study; France; pharmacoepidemiology

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1365-2125.2000.00108.x

Affiliations: 1: Department of Pharmacology, Victor Segalen Bordeaux 2 University, Bordeaux, 2: Public Health Department, Paul Brousse Hospital, Villejuif, 3: Lilly France, Saint Cloud, 4: Department of Psychiatry, Fernand Widal Hospital, Paris, France

Publication date: 2000-01-01

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