IngentaConnect Pulmonary administration of aerosolised fentanyl: pharmacokinetic...

Authors: Mather L.E.¹; Woodhouse A.¹; Ward M.E.¹; Farr S.J.²; Rubsamen R.A.²; Eltherington L.G.²

Source: British Journal of Clinical Pharmacology, Volume 46, Number 1, July 1998 , pp. 37-43(7)

Abstract:

Aims Pulmonary drug delivery is a promising noninvasive method of systemic administration. Our aim was to determine whether a novel breath-actuated, microprocessor-controlled metered dose oral inhaler (SmartMist^TM, Aradigm Corporation) could deliver fentanyl in a way suitable for control of severe pain.

Methods Aersolised pulmonary fentanyl base 100–300 mgr

g was administered to healthy volunteers using SmartMist^TM and the resultant plasma concentration-time data were compared with those from the same doses administered by intravenous (i.v.) injection in the same subjects.

Results Plasma concentrations from SmartMist^TM were similar to those from i.v. injection. Time-averaged bioavailability based upon nominal doses averaged 100%, and was >50% within 5 min of delivery. Fentanyl systemic pharmacokinetics were similar to those previously reported with no trends to dose-dependence from either route. Side-effects (e.g. sedation, lightheadedness) were the same from both routes.

Conclusions Fentanyl delivery using SmartMist^TM can provide analgetically relevant plasma drug concentrations. This, combined with its ease of noninvasive use and transportability, suggests a strong potential for field and domicilliary use, and for patient controlled analgesia without the need for i.v. cannulae.

Keywords: bioavailability; fentanyl; pharmacokinetics; pulmonary administration

Document Type: Research article

DOI: 10.1046/j.1365-2125.1998.00035.x

Affiliations: 1: Department of Anaesthesia and Pain Management, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia, 2: Aradigm Corporation, 26219 Eden Landing Road, Hayward, CA 94545, USA

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Pulmonary administration of aerosolised fentanyl: pharmacokinetic analysis of systemic delivery