@article {Klejnot:2012:0907-4449:154,
	author = "Klejnot, Marta and Kozielski, Frank",
	title = "Structural insights into human Kif7, a kinesin involved in Hedgehog signalling",
	journal = "Acta Crystallographica Section D",
	volume = "68",
	number = "2",
	year = "2012",
	abstract = "Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic development. Kif7 and Kif27, a closely related kinesin in the same subfamily, are orthologues of the <I>Drosophila melanogaster</I> kinesin-like protein Costal-2 (Cos2). In vertebrates, they work together to fulfil the role of the single Cos2 gene in <I>Drosophila.</I> Here, the high-resolution structure of the human Kif7 motor domain is reported and is compared with that of conventional kinesin, the founding member of the kinesin superfamily. These data are a first step towards structural characterization of a kinesin-4 family member and of this interesting molecular motor of medical significance.",
	pages = "154-159",
	url = "http://www.ingentaconnect.com/content/bsc/ayd/2012/00000068/00000002/art00008",
	doi = "doi:10.1107/S0907444911053042"
}