The racemic title compound, C17H23N3O3, isolated from the reaction of
l‐(−)‐tyrosine hydrazide with triethyl orthopropionate in the presence of a catalytic quantity of p‐toluenesulfonic
acid (p‐TsOH), crystallizes with Z′ = 1 in a centrosymmetric monoclinic unit cell. The molecule contains two planar fragments, viz. the benzene and imidazole rings, linked by two C—C single bonds. The dihedral angle between the two planes is 59.54 (5)°
and the molecule adopts a synclinal conformation. The HOMA (harmonic oscillator model of aromaticity) index, calculated for the benzene ring, demonstrates no substantial interaction between the two π‐electron delocalization regions in the molecule. In the crystal structure, there
is an O—H...N hydrogen bond that links the molecules along the c axis.
No Supplementary Data
Document Type: Research Article
Publication date: 2012-03-15