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Molecular conformation and supramolecular aggregation in two fused pyrazoles: -stacked R (6) dimers in 2,8,8-tri­methyl-6,7,8,9-tetra­hydro­pyrazolo­[2,3-a]­quinazolin-6-one, and sheets of alternating R (12) and R (48) rings in 3-tert-butyl-4′,4′-di­methyl-1-phenyl-4,5,6,7-tetra­hydro-1H-pyrazolo­[3,4-b]­pyridine-5-spiro-1′-cyclo­hexane-2′,6′-dione

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In 2,8,8-tri­methyl-6,7,8,9-tetra­hydro­pyrazolo­[2,3-a]­quin­azolin-6-one, C13H15N3O, (I), the heterobicyclic system is planar and exhibits peripheral ten -electron delocalization. In 3-tert-butyl-4′,4′-di­methyl-1-phenyl-4,5,6,7-tetra­hydro-1H- pyrazolo­[3,4-b]­pyridine-5-spiro-1′-cyclo­hexane-2′,6′-dione, C23H25N3O2, (II), the pyrazole ring exhibits marked bond fixation, while the reduced pyridine ring adopts a half-chair conformation. Molecules of (I) are linked into centrosymmetric (6) dimers by a single C—H…N hydrogen bond [H…N = 2.50 Å, C…N = 3.3397 (17) Å and C—H…N = 148°], and these dimers are linked into chains by a single – stacking interaction. In (II), the combined action of one N—H…O hydrogen bond [H…O = 2.40 Å, N…O = 3.2248 (15) Å and N—H…O = 157°] and one C—H…O hydrogen bond [H…O = 2.48 Å, C…O = 3.407 (2) Å and C—H…O = 164°] links the mol­ecules into sheets built from alternating centrosymmetric (12) and (48) rings; there is a weak C—H…N interaction [H…N = 2.60 Å, C…N = 3.5149 (18) Å and C—H…N = 154°] between mol­ecules in adjacent sheets.

Document Type: Research Article


Publication date: April 1, 2004


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