A central problem in crystallography is crystal structure determination directly from diffraction intensities. For structures of small molecules, this problem has been addressed by probabilistic direct methods that allow one to obtain the structure coordinates with a high degree of
certainty given a sufficiently large set of intensities. In contrast, deterministic algebraic methods that could guarantee a solution and may be applicable to macromolecules have not yet emerged. In this study a basic algebraic question is posed: how many crystal structures can be obtained
from a given set of intensities? Recently, by using a new origin definition and the method of elementary symmetrical polynomials, all small (N≤ 4 atoms) one‐dimensional crystal structures that could be obtained from the minimum set of N− 1 lowest‐resolution
intensities were enumerated. Here, by using methods of modern algebraic geometry the maximum number of one‐dimensional crystal structures that can be determined from the minimum set of intensities for N > 4 is obtained. It is demonstrated that this ambiguity increases exponentially
with the increasing number of atoms in the structure N (∼4N/N3/2 for N >> 1) and includes non‐homometric structures. Therefore, a minimum set of intensities, even in principle, is insufficient for structure determination for
all but very small structures.