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Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia

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 To report on a trial of adding amisulpride to clozapine. Methods:

 Description of six cases. Results:

 Six patients who had been on clozapine were commenced on amisulpride. All patients had had unwanted effects with clozapine, particularly sedation, hypersalivation, or weight gain. Five patients reported a high level of satisfaction with the regimen, having a reduction in the level of sedation and improvement in levels of motivation and energy, without recurrence of positive symptoms. Conclusion:

 The combined use of amisulpride and clozapine would appear to be an appropriate and beneficial treatment.

Keywords: amisulpride; clozapine; polypharmacy; treatment-resistant schizophrenia

Document Type: Case Report


Publication date: 2004-03-01

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