Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia
To report on a trial of adding amisulpride to clozapine. Methods:
Description of six cases. Results:
Six patients who had been on clozapine were commenced on amisulpride. All patients had had unwanted effects with clozapine, particularly sedation, hypersalivation, or weight gain. Five patients reported a high level of satisfaction with the regimen, having a reduction in the level of sedation and improvement in levels of motivation and energy, without recurrence of positive symptoms. Conclusion:
The combined use of amisulpride and clozapine would appear to be an appropriate and beneficial treatment.