Authors: ARMSTRONG, D.¹; JAMES, C.¹; CAMACHO, F.²; CHEN, Y.¹; HORBAY, G. L. A.³; TEIXEIRA, B.³; HUSEIN-BHABHA, F. A.³

Source: Alimentary Pharmacology & Therapeutics, Volume 25, Number 2, January 2007 , pp. 185-196(12)

Publisher: Wiley-Blackwell

Abstract:

Summary Background

Intravenous pantoprazole is often administered inappropriately to hospitalized patients who can take oral medications. Aim

To compare the antisecretory effects of oral rabeprazole and intravenous pantoprazole in healthy subjects. Methods

In a double-blind, double-dummy, two-way crossover study, 38 Helicobacter pylori-negative volunteers were randomized to oral rabeprazole 20 mg or intravenous pantoprazole 40 mg daily for 3 days followed, after a 14-day washout period by the comparator treatment. Intragastric pH was recorded continuously for 24 h at baseline and on days 1 and 3 of each treatment period. Results

The mean (95% CI) percentage of the 24-h recording with gastric pH >4 was higher with rabeprazole than with pantoprazole on day 1: 37.7% (30.6-44.8%) vs. 23.9% (20.0-27.8). The mean percentage times with pH >3 and >4 for all intervals assessed were greater and the median 24-h intragastric pH values were higher with rabeprazole than with pantoprazole on days 1 and 3. The mean acidity index was lower with rabeprazole on days 1 and 3. Conclusions

Oral rabeprazole 20 mg produced greater acid suppression than intravenous pantoprazole 40 mg. Therefore, it may be an appropriate and effective alternative in patients who can take oral medication.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2036.2006.03160.x

Affiliations: 1: Division of Gastroenterology, McMaster University, Hamilton, ON; 2: DAMOS Inc., Toronto, ON 3: Clinical Affairs, Janssen-Ortho Inc., Toronto, ON, Canada

Publication date: 2007-01-01

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• In this Subject: Pathology ,  Pharmacology ,  Surgery ,  Therapeutics & Alternative Medicine
• By this author: ARMSTRONG, D. ;  JAMES, C. ;  CAMACHO, F. ;  CHEN, Y. ;  HORBAY, G. L. A. ;  TEIXEIRA, B. ;  HUSEIN-BHABHA, F. A.

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