Authors: GAWROŃSKA, A.¹; DZIECHCIARZ, P.¹; HORVATH, A.²; SZAJEWSKA, H.²

Source: Alimentary Pharmacology & Therapeutics, Volume 25, Number 2, January 2007 , pp. 177-184(8)

Publisher: Wiley-Blackwell

Abstract:

Summary Background

Functional abdominal pain disorders (FAPD) are common in school-aged children; however, there is no reliable treatment. Aim

To determine the efficacy of Lactobacillus rhamnosus GG (LGG) for treating FAPD in children. Methods

A total of 104 children who fulfilled the Rome II criteria for functional dyspepsia (FD), or irritable bowel syndrome (IBS), or functional abdominal pain (FAP) were enrolled in a double-blind, randomized controlled trial in which they received LGG (n = 52), or placebo (n = 52) for 4 weeks. Results

For the overall study population, those in the LGG group were more likely to have treatment success (no pain) than those in the placebo group (25% vs. 9.6%, relative benefit (RB) 2.6, 95% confidence interval (CI): 1.05-6.6, number needed to treat (NNT) 7, 95% CI: 4-123). For children with IBS (n = 37), those in the LGG group were more likely to have treatment success than those in the placebo group (33% vs. 5%, RB 6.3, 95% CI: 1.2-38, NNT 4, 95% CI: 2-36) and reduced frequency of pain (P = 0.02), but not pain severity (P = 0.10). For the FD group (n = 20) and FAP group (n = 47), no differences were found. Conclusion

The LGG appears to moderately increase treatment success, particularly among children with IBS.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2036.2006.03175.x

Affiliations: 1: Department of Paediatric Gastroenterology and Nutrition, The Medical University of Warsaw, Warsaw 2: The Second Department of Paediatrics (II Katedra Pediatrii), The Medical University of Warsaw, Warsaw, Poland

Publication date: 2007-01-01

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