Authors: MINER, P. B.¹; ALLGOOD, L. D.²; GRENDER, J. M.²

Source: Alimentary Pharmacology & Therapeutics, Volume 25, Number 1, January 2007 , pp. 103-109(7)

Publisher: Wiley-Blackwell

Abstract:

Summary Background

The onset of acid inhibition for proton pump inhibitors is slower than with H₂RAs and generally considered to be at a steady-state after 5 days. Thus, little direct comparison data exists between H₂RAs and proton pump inhibitors for gastric acid suppression on day 1 of therapy. Furthermore, the durability of their acid suppression has not been systematically compared. Aim

To compare the effects of 20.6 mg omeprazole magnesium o.m. (Ome-Mg 20), famotidine 10 mg b.d. (Fam 10) and famotidine 20 mg b.d. (Fam 20) on intragastric pH on day 1 and throughout 14 days of dosing. Methods

The study was a randomized, double-blind, three-dosing regimens, three-period crossover. Healthy adults with frequent heartburn (≥2 days/week) underwent 24-h gastric pH monitoring on days 0 (baseline), 1, 3, 7 and 14. Results

Thirty-one subjects were included in the per-protocol analyses. On day 1, the mean percentage time pH > 4 (pH4%) was higher for Ome-Mg 20, 44.6%, than for Fam 10, 36.7% (P = 0.032), and not different from Fam 20, 46.9% (P = 0.541). The pH4% was higher for Ome-Mg 20 than either famotidine regimen on all subsequent monitoring days (P < 0.001). The 24-h area under the mean intragastric pH curve showed a similar pattern. Furthermore, after day 1, Ome-Mg 20 demonstrated an increasing and sustained effect in contrast to a decreasing effect for famotidine, consistent with H₂RA tolerance. Conclusion

Gastric acid suppression on Ome-Mg 20 mg o.m. over 14 days was comparable with Fam 10 mg b.d. or Fam 20 mg b.d. on day 1, and superior thereafter.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2036.2006.03129.x

Affiliations: 1: Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA 2: The Procter & Gamble Company, Cincinnati, OH, USA

Publication date: 2007-01-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Pathology ,  Pharmacology ,  Surgery ,  Therapeutics & Alternative Medicine
• By this author: MINER, P. B. ;  ALLGOOD, L. D. ;  GRENDER, J. M.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers