Authors: CANAVAN, C.¹; ABRAMS, K. R.²; HAWTHORNE, B.³; MAYBERRY, J. F.¹

Source: Alimentary Pharmacology & Therapeutics, Volume 25, Number 1, January 2007 , pp. 59-65(7)

Publisher: Wiley-Blackwell

Abstract:

Summary Aim

To investigate the incidence of death in patients diagnosed with Crohn's disease in Cardiff over 20 years ago. Methods

The Cardiff database of patients with Crohn's disease contains data on all patients diagnosed there since 1934. Patients (394) diagnosed before 1 January 1985 were traced and their mortality status on 31 December 2004 was established. Results

The overall standardized mortality ratio (SMR) was 1.29 (95% CI 1.12-1.45) and it has not significantly changed since the 1970s. SMR decreases with age, from 16.95 (95% CI 14.99-18.91) for patients aged 10-19 years (although only one death) to 0.92 (95% CI 0.65-1.19) in those over 75 years. Kaplan-Meier analysis of age at death shows that patients diagnosed aged 10-26 years have median age at death of 58 years, those aged 27-52 years of 66 years, those aged 53-58 years of 74 years, and those over 59 years of 79 years. Conclusions

It shows a significantly raised SMR, not statistically changed since the 1970s and similar to other chronic conditions. Patients diagnosed younger have worse prognosis than those diagnosed later in life and a reduced life expectancy compared with the general population.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2036.2006.03132.x

Affiliations: 1: Digestive Diseases Centre, University Hospitals of Leicester, Leicester General Hospital, Gwendolen Road, Leicester 2: Centre for Biostatistics and Genetic Epidemiology, Department of Heath Sciences, University of Leicester 3: University Hospital of Wales, Heath Park, Cardiff, UK

Publication date: 2007-01-01

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