Alimentary Pharmacology & Therapeutics

Guest Editors and Committees
pp. ii-ii(1)

Foreword
pp. vii-vii(1)

Preface
pp. viii-viii(1)

Significance of activated mast cells in submucosa and muscularis propria of patients with Crohn's disease detected by a novel antimast cell surface molecule antibody
pp. 1-7(7)
Authors: OSHITANI, N.; KAMATA, N.; INAGAWA, M.; YAMAGAMI, H.; WATANABE, K.; FUJIWARA, Y.; HIGUCHI, K.; ARAKAWA, T.; OKADA, T.

Helicobacter pylori infection induces accumulation of Vδ1 T cells via CCR2 upregulation
pp. 8-15(8)
Authors: FUTAGAMI, S.; HIRATSUKA, T.; SHINDO, T.; HAMAMOTO, T.; UEKI, N.; SUZUKI, K.; KUSUNOKI, M.; WADA, K.; MIYAKE, K.; OHASHI, K.; GUDIS, K.; TSUKUI, T.; SAKAMOTO, C.

Comparison of efficacies of dual therapy and triple therapy using rabeprazole in second-line eradication of Helicobacter pylori in Japan
pp. 16-22(7)
Authors: KAWAI, T.; KAWAKAMI, K.; KATAOKA, M.; TAIRA, S.; ITOI, T.; MORIYASU, F.; TAKAGI, Y.; AOKI, T.; RIMBARA, E.; NOGUCHI, N.; SASATSU, M.

Correlation of serum pepsinogen with histological atrophy following successful Helicobacter pylori eradication
pp. 23-30(8)
Authors: KAWAI, T.; KAWAKAMI, K.; KATAOKA, M.; TAKEI, K.; TAIRA, S.; ITOI, T.; MORIYASU, F.; TAKAGI, Y.; AOKI, T.; SERIZAWA, H.; RIMBARA, E.; NOGUCHI, N.; SASATSU, M.

Review article: is there a common principle in the development of gastrointestinal cancers? Stem cells in the origin of cancer
pp. 31-40(10)
Author: WRIGHT, N. A.

Efficacy of proton pump inhibitors for cellular proliferation and apoptosis in Barrett's oesophagus with different mucin phenotypes
pp. 41-48(8)
Authors: AMANO, Y.; CHINUKI, D.; YUKI, T.; TAKAHASHI, Y.; ISHIMURA, N.; KAZUMORI, H.; KUSHIYAMA, Y.; KARIM RUMI, M. A.; ISHIHARA, S.; KINOSHITA, Y.

Interactions between the grading of gastric atrophy associated with Helicobacter pylori infection and the severity of clinical symptoms and delay in gastric emptying in patients with functional dyspepsia
pp. 49-57(9)
Authors: KADOUCHI, K.; TOMINAGA, K.; OCHI, M.; KAWAMURA, E.; SASAKI, E.; SHIBA, M.; WATANABE, T.; FUJIWARA, Y.; OSHITANI, N.; HIGUCHI, K.; SHIOMI, S.; ARAKAWA, T.

Changes in biochemical parameters related to atherosclerosis after Helicobacter pylori eradication
pp. 58-64(7)
Authors: ANDO, T.; MINAMI, M.; ISHIGURO, K.; MAEDA, O.; WATANABE, O.; MIZUNO, T.; FUJITA, T.; TAKAHASHI, H.; NOSHIRO, M.; GOTO, H.

Infliximab regulates lamina propria T lymphocytes in patients with Crohn's disease
pp. 65-70(6)
Authors: WATANABE, O.; ANDO, T.; FURUTA, R.; MAEDA, O.; ISHIGURO, K.; TAKAHASHI, H.; INA, K.; KUSUGAMI, K.; GOTO, H.

Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer exhibits sonic hedgehog loss and aberrant CDX2 expression
pp. 71-80(10)
Authors: SHIOTANI, A.; IISHI, H.; UEDO, N.; ISHIHARA, R.; ISHIGURO, S.; TATSUTA, M.; NAKAE, Y.; KUMAMOTO, M.; HINOI, T.; MERCHANT, J. L.

Could frameshift mutations in the frxA and rdxA genes of Helicobacter pylori be a marker for metronidazole resistance?
pp. 81-87(7)
Authors: MASAOKA, T.; SUZUKI, H.; KURABAYASHI, K.; NOMOTO, Y.; NISHIZAWA, T.; MORI, M.; HIBI, T.

Colonic mucosal lesions associated with long-term administration of non-steroidal anti-inflammatory drugs
pp. 88-95(8)
Authors: OHKUSA, T.; TERAI, T.; ABE, S.; KOBAYASHI, O.; BEPPU, K.; SAKAMOTO, N.; KUROSAWA, A.; OSADA, T.; HOJO, M.; NAGAHARA, A.; OGIHARA, T.; SATO, N.

Intravenous ghrelin administration enhances gastric acid secretion - evaluation using wireless pH capsule
pp. 96-103(8)
Authors: MORI, M.; SUZUKI, H.; MASAOKA, T.; IMAEDA, H.; NOMOTO, Y.; HOSODA, H.; NISHIZAWA, T.; KANGAWA, K.; HIBI, T.

Enhanced plasma ghrelin levels in patients with functional dyspepsia
pp. 104-110(7)
Authors: NISHIZAWA, T.; SUZUKI, H.; NOMOTO, Y.; MASAOKA, T.; HOSODA, H.; MORI, M.; OHARA, T.; MORISHITA, T.; KANGAWA, K.; HIBI, T.

Evaluation of the role of Helicobacter pylori as a promoter of gastric cancer from the viewpoint of structural chromosomal aberration
pp. 111-119(9)
Authors: OHARA, T.; KASANUKI, J.; MORISHITA, T.; YAMAMOTO, N.; SHIBAHARA, T.; SUZUKI, H.; MASAOKA, T.; NISHIZAWA, T.; HIBI, T.

Increased levels of plasma ghrelin in peptic ulcer disease
pp. 120-126(7)
Authors: SUZUKI, H.; MASAOKA, T.; NOMOTO, Y.; HOSODA, H.; MORI, M.; NISHIZAWA, T.; MINEGISHI, Y.; KANGAWA, K.; HIBI, T.

Interaction between Helicobacter pylori and immune response to CagA: CagA antibody may down-regulate bacterial colonization and tyrosine phosphorylation
pp. 127-131(5)
Authors: DEGUCHI, R.; WATANABE, K.; KOGA, Y.; KIJIMA, H.; TAKAGI, A.

Gastric motility and autonomic activity during obstructive sleep apnea
pp. 132-140(9)
Authors: URATA, M.; FUKUNO, H.; NOMURA, M.; OGATA, T.; ITO, S.; NAKAYASU, K.; NAKAYA, Y.

Evaluation of gastro-oesophageal flap valve is useful for diagnosing gastro-oesophageal reflux disease
pp. 141-146(6)
Authors: IWAMOTO, M.; KATO, K.; MIZUNO, S.; MIYAMOTO, S.; TAKEUCHI, R.; IWASAKI, A.; ARAKAWA, Y.

Efficacy and endoscopic prediction of cytapheresis therapy in patients with refractory and steroid-dependent ulcerative colitis
pp. 147-152(6)
Authors: WATANABE, K.; OSHITANI, N.; KAMATA, N.; INAGAWA, M.; YAMAGAMI, H.; HIGUCHI, K.; ARAKAWA, T.

Differential expression of cyclo-oxygenase-2 and nuclear β-catenin in colorectal cancer tissue
pp. 153-159(7)
Authors: TATSUGUCHI, A.; KISHIDA, T.; FUJIMORI, S.; TANAKA, S.; GUDIS, K.; SHINJI, S.; FURUKAWA, K.; TAJIRI, T.; SUGISAKI, Y.; FUKUDA, Y.; SAKAMOTO, C.

Relationship between ghrelin and Helicobacter pylori infection in Polish adult shepherds and their children
pp. 160-168(9)
Authors: PLONKA, M.; KONTUREK, P. C.; BIELANSKI, W.; PAWLIK, T.; BRZOZOWSKI, T.; KONTUREK, S. J.

Review article: duodenal bicarbonate - mucosal protection, luminal chemosensing and acid-base balance
pp. 169-176(8)
Authors: KAUNITZ, J. D.; AKIBA, Y.

Evaluation of alcohol metabolism in humans using the non-invasive [¹³C]-ethanol breath test - influence of gender, Helicobacter pylori infection and polymorphism of alcohol-oxidizing enzymes
pp. 177-181(5)
Authors: SUZUKI, M.; TANAKA, S.; KOMATSU, H.; NAKANE, T.; SASAKI, N.; MARUYAMA, K.; SUZUKI, H.; ISHII, H.; SUEMATSU, M.; HIBI, T.

Hypoxia-inducible factor-1 alpha and vascular endothelial growth factor expression in ischaemic colitis and ulcerative colitis
pp. 182-188(7)
Authors: OKUDA, T.; AZUMA, T.; OHTANI, M.; MATSUNAGA, S.; MASAKI, R.; SATOMI, S.; INAGAKI, T.; MURAMATSU, A.; LEE, S.; SUTO, H.; ITO, Y.; YAMAZAKI, Y.; ITO, S.; KURIYAMA, M.

High prevalence of Helicobacter pylori infection in Japanese patients with membranous nephropathy
pp. 189-193(5)
Authors: MORIYAMA, T.; KANEKO, T.; FUJII, M.; TSUBAKIHARA, Y.; KAWANO, S.; IMAI, E.

Effect of eradication of Helicobacter pylori on genetic instabilities in gastric intestinal metaplasia
pp. 194-202(9)
Authors: TANAKA, A.; WATARI, J.; TANABE, H.; MAEMOTO, A.; FUJIYA, M.; ASHIDA, T.; DAS, K. M.; KOHGO, Y.

Helicobacter pylori eradication prevents the development of gastric cancer - results of a long-term retrospective study in Japan
pp. 203-206(4)
Authors: KATO, M.; ASAKA, M.; NAKAMURA, T.; AZUMA, T.; TOMITA, E.; KAMOSHIDA, T.; SATO, K.; INABA, T.; SHIRASAKA, D.; OKAMOTO, S.; TAKAHASHI, S.; TERAO, S.; SUWAKI, K.; ISOMOTO, H.; YAMAGATA, H.; NOMURA, H.; YAGI, K.; SONE, Y.; URABE, T.; AKAMATSU, T.; OHARA, S.; TAKAGI, A.; MIWA, J.; INATSUCHI, S.

Coinfection of Helicobacter pylori and Neisseria subflava is closely associated with lymph follicle formation in human stomach
pp. 207-213(7)
Authors: NAKAMURA, M.; MATSUI, H.; SERIZAWA, H.; MURAYAMA, S. Y.; YAMAGUCHI, T.; TAKAHASHI, T.; MATSUMOTO, T.; YAMADA, H.; HIBI, T.; TSUCHIMOTO, K.

Helicobacter pylori eradication and metachronous gastric cancer after endoscopic mucosal resection of early gastric cancer
pp. 214-218(5)
Authors: NAKAGAWA, S.; ASAKA, M.; KATO, M.; NAKAMURA, T.; KATO, C.; FUJIOKA, T.; TATSUTA, M.; KEIDA, K.; TERAO, S.; TAKAHASHI, S.; UEMURA, N.; KATO, T.; AOYAMA, N.; SAITO, D.; SUZUKI, M.; IMAMURA, A.; SATO, K.; MIWA, H.; NOMURA, H.; KAISE, M.; OOHARA, S.; KAWAI, T.; URABE, K.; SAKAKI, N.; ITO, S.; NODA, Y.; YANAKA, A.; KUSUGAMI, K.; GOTO, H.; FURUTA, T.; FUJINO, M.; KINJYOU, F.; OOKUSA, T.

Molecular mechanisms involved in interleukin-8 production by normal human oesophageal epithelial cells
pp. 219-226(8)
Authors: YOSHIDA, N.; IMAMOTO, E.; UCHIYAMA, K.; KURODA, M.; NAITO, Y.; MUKAIDA, N.; KAWABE, A.; SHIMADA, Y.; YOSHIKAWA, T.; OKANOUE, T.

Distribution comparison of depressed vs. non-depressed early colorectal cancers
pp. 227-232(6)
Authors: SAKAMOTO, N.; TERAI, T.; OHKUSA, T.; ABE, S.; BEPPU, K.; KOBAYASHI, O.; HIRAI, S.; KONNO, A.; NAMIHISA, A.; OGIHARA, T.; FUJII, H.; MIWA, H.; SATO, N.

Increased intestinal luminal carbon monoxide gas in patients with ulcerative colitis
pp. 233-238(6)
Authors: TAKAGI, T.; NAITO, Y.; TSUBOI, H.; ISOZAKI, Y.; KATADA, K.; SUZUKI, T.; TERAO, K.; HANDA, O.; KOKURA, S.; ICHIKAWA, H.; YOSHIDA, N.; OKUYAMA, Y.; YAGI, N.; UEDA, H.; YOSHIKAWA, T.

Host serological response to Helicobacter pylori after successful eradication: long-term follow-up in patients with cured and persistent infection
pp. 239-248(10)
Authors: TANAKA, J.; OHKUSA, T.; YOKOYAMA, T.; MATSUHISA, T.; KAWAI, T.; HASHIMOTO, H.; TOMITA, T.; HORI, K.; NAKAJIMA, K.; MATSUMOTO, T.; MIWA, H.

Review article: anti-tryptase therapy in inflammatory bowel disease
pp. 249-255(7)
Authors: YOSHIDA, N.; ISOZAKI, Y.; TAKAGI, T.; TAKENAKA, S.; UCHIKAWA, R.; ARIZONO, N.; YOSHIKAWA, T.; OKANOUE, T.

Gene expression clusters of a lipopolysaccharide-stimulated pathway in peripheral blood monocytes of Japanese patients with Crohn's disease
pp. 256-265(10)
Authors: NAITO, Y.; TAKAGI, T.; MIZUSHIMA, K.; UETA, M.; KINOSHITA, S.; HANDA, O.; KOKURA, S.; ICHIKAWA, H.; YOSHIDA, N.; YOSHIKAWA, T.

Phase I study of paclitaxel plus irinotecan combination therapy for patients with refractory and advanced gastric cancer
pp. 266-271(6)
Authors: KOBAYASHI, T.; SAKAGAMI, T.; KOIZUKA, H.; YAMAMOTO, N.; SASAKI, T.; MAEDA, Y.; OMURO, Y.; OKAMOTO, R.; MIKOSHIBA, M.; SASAKI, E.; MATSUMOTO, T.; MIWA, H.

Enhancement of cytoprotective ability and cell restoration in 70-kDa heat shock protein gene-transfected rat gastric mucosal cells
pp. 272-277(6)
Authors: OTAKA, M.; MATSUHASHI, T.; ODASHIMA, M.; ITOH, H.; JIN, M.; WADA, I.; KOMATSU, K.; HORIKAWA, Y.; OHBA, R.; OYAKE, J.; HATAKEYAMA, N.; WATANABE, S.

Helicobacter pylori eradication therapy modulates acidity and interleukin-1β mRNA levels in un-operated stomach and in remnant stomach after gastrectomy in gastric cancer patients
pp. 278-284(7)
Authors: KATO, S.; MATSUKURA, N.; MATSUDA, N.; TSUKADA, K.; NAITO, Z.; TAJIRI, T.

Review article: regulation of TFF1 (pS2) expression in gastric epithelial cells
pp. 285-291(7)
Authors: FUJII, Y.; SHIMADA, T.; KOIKE, T.; HOSAKA, K.; TABEI, K.; NAMATAME, T.; TAJIMA, A.; YONEDA, M.; TERANO, A.; HIRAISHI, H.

Discrimination between gastric ectopic pancreas and mesenchymal tumours, including GIST - from 12 years` surgical experience in one institute
pp. 292-296(5)
Authors: OTANI, Y.; YOSHIDA, M.; SAIKAWA, Y.; WADA, N.; KUBOTA, T.; KUMAI, K.; SUGINO, Y.; MUKAI, M.; KAMEYAMA, K.; KITAJIMA, M.

Twelve years' progress in surgery for perforated gastric and duodenal ulcers: a retrospective study of indications for laparoscopic surgery, post-operative course and the influence of Candida infection
pp. 297-302(6)
Authors: NAKAMURA, T.; YOSHIDA, M.; OTANI, Y.; KAMEYAMA, K.; ISHIKAWA, H.; KUMAI, K.; KUBOTA, T.; SAIKAWA, Y.; KITAJIMA, M.

Endoscopic classifications as diagnostic factors of peptic ulcer and early gastric cancer - a possible reason why Helicobacter pylori infection causes gastric ulcers along lesser curvature
pp. 303-310(8)
Authors: YOSHIDA, M.; SAIKAWA, Y.; HOSODA, S.; KUMAI, K.; KUBOTA, T.; ISHIKAWA, H.; NAKAMURA, T.; NAKAMURA, R.; KAMEYAMA, K.; TAKAHASHI, S.; KURIHARA, N.; KITAJIMA, M.

Reviewers
pp. 311-311(1)