Authors: CHAN, H. L.-Y.; TSE, A. M.-L.; ZHANG, M.-D.; WONG, V. W.-S.; CHIM, A. M.-L.; HUI, A. Y.; SUNG, J. J.-Y.

Source: Alimentary Pharmacology & Therapeutics, Volume 23, Number 12, June 2006 , pp. 1703-1711(9)

Publisher: Wiley-Blackwell

Abstract:

Summary Background

Interleukin-1β is a pro-inflammatory cytokine that may influence host defence against viral infection. Aim

To investigate the impact of interleukin-1β gene polymorphism on the response to anti-viral treatment. Method

Hepatitis B e antigen-positive chronic hepatitis B patients who have completed a randomized study of peginterferon alpha-2b and lamivudine combination vs. lamivudine monotherapy were included. Sustained responders were patients who had persistent hepatitis B e antigen loss and less than two occasions with hepatitis B virus DNA >100 000 copies/mL at any time up to week 76 post-treatment. Polymorphisms at interleukin-1β-511, -31 and -3954 and interleukin-1 receptor antagonist (RN) were studied. Results

Eighty-eight patients were studied and 18 (20%) patients developed sustained response. Near complete linkage disequilibrium was observed between interleukin-1β-511 and -31 loci. After adjustment for the potential confounding effects of treatment allocation, hepatitis B virus genotype, pre-treatment alanine aminotransferase and hepatitis B virus DNA levels, genotype C/T at interleukin-1β-511 was found to be associated with higher sustained response than genotype C/C (adjusted odds ratio 10.4, 95% CI 1.1, 96.9, P = 0.040). The proportion of sustained responders tend to be higher among patients with allele T at interleukin-1β-511 (83%) than those without (70%) (P = 0.058). Conclusion

High interleukin-1β production genotype at position -511 has a favourable response to anti-viral treatments.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2036.2006.02948.x

Publication date: 2006-06-01

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• In this Subject: Pathology ,  Pharmacology ,  Surgery ,  Therapeutics & Alternative Medicine
• By this author: CHAN, H. L.-Y. ;  TSE, A. M.-L. ;  ZHANG, M.-D. ;  WONG, V. W.-S. ;  CHIM, A. M.-L. ;  HUI, A. Y. ;  SUNG, J. J.-Y.

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