Authors: SHAPIRO, M.; GREEN, C.; FAYBUSH, E. M.; ESQUIVEL, R. F.; FASS, R.

Source: Alimentary Pharmacology & Therapeutics, Volume 23, Number 2, January 2006 , pp. 321-329(9)

Publisher: Wiley-Blackwell

Abstract:

Summary Background 

Studies have demonstrated that patients with Barrett's oesophagus have the highest oesophageal acid exposure profile, followed by erosive oesophagitis and non-erosive reflux disease patients, but the exact extent of overlap remains unknown. Aim 

To determine the extent of overlap in oesophageal acid exposure among the different gastro-oesophageal reflux disease groups. Methods 

A total of 121 patients with gastro-oesophageal reflux disease underwent an upper endoscopy and were classified as having Barrett's oesophagus, erosive oesophagitis and non-erosive reflux disease-all (non-erosive reflux disease-positive and functional heartburn). Subsequently, patients underwent pH testing and overlap in oesophageal acid exposure among the different gastro-oesophageal reflux disease groups was determined. Results 

Of those enrolled, 24 had Barrett's oesophagus, 30 erosive oesophagitis and 28 were non-erosive reflux disease-positive. Mean oesophageal acid exposure time was 224.8 ± 35, 134.3 ± 21.9 and 141.3 ± 19.8 min for Barrett's oesophagus, erosive oesophagitis and non-erosive reflux disease-positive respectively. Per cent overlap for total, upright and supine time between non-erosive reflux disease-positive and erosive oesophagitis was 47.4%, 64.7% and 81.8%, between Barrett's oesophagus and erosive oesophagitis was 47.8%, 40.7% and 24%, and between Barrett's oesophagus and non-erosive reflux disease-positive was 31.6%, 37.5% and 20.8% respectively. Conclusions 

Our study demonstrated a high oesophageal acid exposure overlap between patients with non-erosive reflux disease-positive and erosive oesophagitis, Barrett's oesophagus and erosive oesophagitis, as well as Barrett's oesophagus and non-erosive reflux disease-positive patients.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2036.2006.02747.x

Publication date: 2006-01-01

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• In this Subject: Pathology ,  Pharmacology ,  Surgery ,  Therapeutics & Alternative Medicine
• By this author: SHAPIRO, M. ;  GREEN, C. ;  FAYBUSH, E. M. ;  ESQUIVEL, R. F. ;  FASS, R.

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