Authors: TOUGAS, G.; EARNEST, D. L.¹; CHEN, Y.²; VANDERKOY, C.²; ROJAVIN, M.¹

Source: Alimentary Pharmacology & Therapeutics, Volume 22, Number 1, July 2005 , pp. 59-65(7)

Publisher: Wiley-Blackwell

Abstract:

Summary Background

: Proton-pump inhibitors effectively suppress stomach acidity. They are widely used for treating gastro-oesophageal reflux disease and related conditions. While generally safe, omeprazole and other proton-pump inhibitors can delay gastric emptying. Aim

: To test the hypothesis that tegaserod can normalize or prevent omeprazole-induced delay in gastric emptying. Methods

: This was a randomized, double-blind, placebo-controlled, parallel group study in 40 healthy male volunteers. After informed consent and screening, qualified volunteers were treated with unblinded omeprazole 20 mg b.d. and either blinded tegaserod 6 mg t.d.s. (active treatment group) or placebo-matching tegaserod t.d.s. (control group) for 14 days. Gastric emptying was assessed before and after treatment, using a scintigraphy method. Results

: Omeprazole monotherapy significantly delayed gastric emptying expressed by duration of lag-phase (P < 0.007), time to gastric half-emptying (P < 0.003), and gastric retention of the meal at 60 (P < 0.002) and 120 min (P < 0.04) after its ingestion. Tegaserod taken together with omeprazole effectively prevented development of the above effects. Combined treatment was safe and well tolerated. Conclusion

: Concomitant administration of tegaserod 6 mg t.d.s. prevented development of the delayed gastric emptying induced by omeprazole monotherapy.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2036.2005.02528.x

Affiliations: 1: Novartis Pharmaceuticals, East Hanover, NJ, USA 2: McMaster University, Hamilton, ON, Canada

Publication date: 2005-07-01

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