@article {Wilder-Smith:November 2004:0953-0673:1099,
author = "Wilder-Smith, C. H.",
author = "Rohss, K.",
author = "Bondarov, P.",
author = "Hallerback, B.",
author = "Svedberg, L.-E.",
author = "Ahlbom, H.",
title = "Esomeprazole 40mg i.v. provides faster and more effective intragastric acid control than pantoprazole 40mg i.v.: results of a randomized study",
journal = "Alimentary Pharmacology & Therapeutics",
volume = "20",
year = "November 2004",
abstract = "Summary Background : Oral esomeprazole 40 mg provides greater acid control than oral pantoprazole 40 mg. Aim : To compare the effects on intragastric acid control of esomeprazole 40 mg administered intravenously with pantoprazole 40 mg intravenously. Methods : Healthy Helicobacter pylori-negative male and female subjects were enrolled into this single-centre, open, randomized, two-way crossover study. Esomeprazole 40 mg intravenously and pantoprazole 40 mg intravenously were administered as 15-min infusions once daily at 09:00 hours for 5 days. Continuous 24-h intragastric pH monitoring was carried out at baseline and on days 1 and 5. Results : pH-data were available for all 25 subjects who completed the study. Esomeprazole 40 mg intravenously resulted in 8.3 and 13.9 h with an intragastric pH > 4 on days 1 and 5 compared with 5.3 and 9.0 h, respectively for pantoprazole 40 mg intravenously (day 1: P < 0.001, day 5: P < 0.0001). During the first 4 h of dosing on day 1 corresponding values were 1.7 and 0.6 h respectively (P < 0.0001). A mean median pH above 4 on day 5 was only attained with esomeprazole 40 mg intravenously. Conclusions : Once-daily dosing with esomeprazole 40 mg intravenously provides faster and more pronounced intragastric acid control than pantoprazole 40 mg intravenously.",
pages = "1099-1104(6)",
url = "http://www.ingentaconnect.com/content/bsc/apt/2004/00000020/00000010/art00012"
doi = "doi:10.1111/j.1365-2036.2004.02272.x"
}