IngentaConnect Effect of low-dose rabeprazole and omeprazole on gastric acidity:...

Authors: Bruley des Varannes, S.¹; Gharib, H.¹; Bicheler, V.¹; Bost, R.²; Bonaz, B.²; Stanescu, L.³; Delchier, J. C.³; Bonnot-Marlier, S.⁴

Source: Alimentary Pharmacology & Therapeutics, Volume 20, Number 8, October 2004 , pp. 899-907(9)

Publisher: Blackwell Publishing

Abstract:

Summary Background

: The treatment of acid-related symptoms requires rapid and consistent acid suppression, especially with on-demand regimens. Aim

: To compare the antisecretory activity of low-dose rabeprazole and omeprazole in healthy, Helicobacter pylori-negative subjects. Methods

: In this randomized, double-blind, placebo-controlled, three-way crossover study, 27 volunteers were given rabeprazole 10 mg, omeprazole 10 mg, or placebo once daily for 7 days with a 10-14-day washout between treatments. Intragastric pH was monitored for 24-h on days 1 and 7 of each treatment. Results

: Median gastric pH was significantly higher with rabeprazole than with omeprazole or placebo: day 1: 2.3, 1.4 and 1.3, respectively (P = 0.0056, rabeprazole vs. omeprazole; P < 0.0001, rabeprazole vs. placebo); day 7: 3.7, 2.2 and 1.3, respectively (P = 0.0016 rabeprazole vs. omeprazole; P < 0.0001, rabeprazole vs. placebo). Time with gastric pH above 4 was significantly higher with rabeprazole than with omeprazole: day 1, 5.8 h vs. 3.7 h, respectively (P < 0.02); day 7, 10.5 h vs. 4.6 h, respectively (P = 0.0008). Conclusions

: Rabeprazole 10 mg provides more rapid acid inhibition compared with omeprazole 10 mg. After 7 days, the time with pH above 4 is more than doubled with rabeprazole 10 mg vs. omeprazole 10 mg.

Document Type: Research article

DOI: 10.1111/j.1365-2036.2004.02176.x

Affiliations: 1: CIC-INSERM, CHU Hôtel Dieu, Nantes, France 2: CHU Grenoble, Grenoble, France 3: CHU Henri Mondor, Creteil, France 4: Laboratoires Janssen-Cilag, Issy Les Moulineaux, France

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Effect of low-dose rabeprazole and omeprazole on gastric acidity: results of a double blind, randomized, placebo-controlled, three-way crossover study in healthy subjects