IngentaConnect Effect of low-dose rabeprazole and omeprazole on gastric acidity:...

Authors: Bruley des Varannes, S.¹; Gharib, H.¹; Bicheler, V.¹; Bost, R.²; Bonaz, B.²; Stanescu, L.³; Delchier, J. C.³; Bonnot-Marlier, S.⁴

Source: Alimentary Pharmacology & Therapeutics, Volume 20, Number 8, October 2004 , pp. 899-907(9)

Publisher: Blackwell Publishing

Abstract:

Summary Background

: The treatment of acid-related symptoms requires rapid and consistent acid suppression, especially with on-demand regimens. Aim

: To compare the antisecretory activity of low-dose rabeprazole and omeprazole in healthy, Helicobacter pylori-negative subjects. Methods

: In this randomized, double-blind, placebo-controlled, three-way crossover study, 27 volunteers were given rabeprazole 10 mg, omeprazole 10 mg, or placebo once daily for 7 days with a 10-14-day washout between treatments. Intragastric pH was monitored for 24-h on days 1 and 7 of each treatment. Results

: Median gastric pH was significantly higher with rabeprazole than with omeprazole or placebo: day 1: 2.3, 1.4 and 1.3, respectively (P = 0.0056, rabeprazole vs. omeprazole; P < 0.0001, rabeprazole vs. placebo); day 7: 3.7, 2.2 and 1.3, respectively (P = 0.0016 rabeprazole vs. omeprazole; P < 0.0001, rabeprazole vs. placebo). Time with gastric pH above 4 was significantly higher with rabeprazole than with omeprazole: day 1, 5.8 h vs. 3.7 h, respectively (P < 0.02); day 7, 10.5 h vs. 4.6 h, respectively (P = 0.0008). Conclusions

: Rabeprazole 10 mg provides more rapid acid inhibition compared with omeprazole 10 mg. After 7 days, the time with pH above 4 is more than doubled with rabeprazole 10 mg vs. omeprazole 10 mg.

Document Type: Research article

DOI: 10.1111/j.1365-2036.2004.02176.x

Affiliations: 1: CIC-INSERM, CHU Hôtel Dieu, Nantes, France 2: CHU Grenoble, Grenoble, France 3: CHU Henri Mondor, Creteil, France 4: Laboratoires Janssen-Cilag, Issy Les Moulineaux, France

You have access to the full text article on a website external to Ingentaconnect.

Please click here to view this article on InterScience.

You may be required to register and activate access on InterScience before you can obtain the full text. If you have any queries please contact onlinehelp@oxon.blackwellpublishing.com

Effect of low-dose rabeprazole and omeprazole on gastric acidity: results of a double blind, randomized, placebo-controlled, three-way crossover study in healthy subjects