IngentaConnect International validation of ReQuest in patients with endoscopy-ne...

Authors: Bardhan, K. D.¹; Stanghellini, V.²; Armstrong, D.³; Berghöfer, P.⁴; Gatz, G.⁴; Mönnikes, H.⁵

Source: Alimentary Pharmacology & Therapeutics, Volume 20, Number 8, October 2004 , pp. 891-898(8)

Abstract:

Summary Background

: Reflux Questionnaire (ReQuest), a newly developed gastro-oesophageal reflux disease-sensitive scale, can be used to reliably evaluate the effect of treatment on gastro-oesophageal reflux disease symptoms. Aim

: International validation of this scale, in patients suffering from endoscopy-negative gastro-oesophageal reflux disease. Methods

: In this open, multicentre and multinational clinical trial 840 endoscopy-negative gastro-oesophageal reflux disease patients received pantoprazole 20 mg daily for 28 days. The long and short versions of ReQuest were completed both in the pre-treatment and treatment phases. For scale development an item reduction analysis was performed. Internal consistency, test-retest reliability and responsiveness were calculated for psychometric analysis. Construct validity was evaluated by comparison with the Gastrointestinal Symptom Rating Scale and the Psychological General Well-being questionnaire by means of correlation coefficients. Results

: Factor analyses confirmed the content validity of both long and short version of ReQuest. Psychometric calculations proved high internal consistency (Cronbach's alpha: 0.9), test-retest reliability [Intraclass Correlation Coefficient: 0.9 (long vs. long) and 0.8 (short vs. short)], and responsiveness (Responsiveness Index 320.3) of the scale, for which also good construct validity was achieved (correlation coefficient: Gastrointestinal Symptom Rating Scale -0.6; Psychological General Well-being −0.4). Conclusion

: ReQuest proved valid, reliable, and responsive in this multinational clinical trial to evaluate treatment response in endoscopy-negative gastro-oesophageal reflux disease patients.

Document Type: Research article

DOI: 10.1111/j.1365-2036.2004.02194.x

Affiliations: 1: District General Hospital, Rotherham, UK 2: S. Orsola Malpighi Hospital, Bologna, Italy 3: McMaster University, Ontario, Canada 4: ALTANA Pharma AG, Konstanz, Germany 5: Charité, Berlin, Germany

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International validation of ReQuest in patients with endoscopy-negative gastro-oesophageal reflux disease