IngentaConnect Serum pepsinogen can predict response to H2-receptor antagonist i...

Authors: Yoshikawa, I.¹; Murata, I.¹; Kume, K.¹; Kanagawa, K.¹; Hirohata, Y.¹; Nakamura, H.¹; Otsuki, M.¹

Source: Alimentary Pharmacology & Therapeutics, Volume 16, Number 10, October 2002 , pp. 1805-1809(5)

Abstract:

Summary Background

: Therapy for the relief of symptoms of functional dyspepsia is unpredictable. Aim

: To identify which patients may benefit from antisecretory therapy. Methods

: Twenty-seven patients with functional dyspepsia were selected to receive H2-receptor antagonist (H2RA) treatment for 4 weeks. Serum pepsinogen A, pepsinogen C and gastrin were measured, and Helicobacter pylori status was determined. Symptoms were assessed at baseline and after H2RA treatment. Results

: Fourteen patients were identified as H2RA responders and the remaining patients were non-responders. No differences were found between responders and non-responders with regard to serum pepsinogen A, pepsinogen C, gastrin and H. pylori status. However, the pepsinogen A/C ratio was significantly higher in responders than in non-responders. Ten of the 13 functional dyspepsia patients (77%) with a high value of the pepsinogen A/C ratio (≥ 4.5) achieved symptom resolution by H2RA, compared with only one of the eight patients (13%) with a low value of the pepsinogen A/C ratio (≤ 3.0). Conclusions

: The serum pepsinogen A/C ratio seems to identify those functional dyspepsia patients for whom acid control provides benefit. This ratio may be a practical tool for the management of functional dyspepsia patients.

Document Type: Research article

DOI: 10.1046/j.1365-2036.2002.01352.x

Affiliations: 1: Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu, Japan

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Serum pepsinogen can predict response to H2-receptor antagonist in patients with functional dyspepsia