IngentaConnect Amoxicillin and ampicillin are not transferred to gastric juice i...

Authors: Ortiz, R. A. M.¹; Calafatti, S. A.¹; Corazzi, A.¹; Souza, J. M.¹; Deguer, M.¹; De Souza, C. A. F.²; Marchioretto, M. A. M.¹; Bernasconi, G.¹; Ferraz, J. G. P.³; Pedrazzoli, J.¹

Source: Alimentary Pharmacology & Therapeutics, Volume 16, Number 6, June 2002 , pp. 1163-1170(8)

Publisher: Blackwell Publishing

Abstract:

Background:

The effects of proton pump inhibitors and Helicobacter pylori infection on the distribution of drugs used for the eradication of the bacteria are poorly understood. Aim:

The aim of this study was to investigate the effects of a 7-day administration of 20 mg of omeprazole on the pharmacokinetics of amoxicillin and ampicillin in the plasma, saliva and gastric juice of individuals with and without H. pylori infection. Methods:

Fifty-four healthy volunteers without endoscopic lesions were enrolled. Twenty-six volunteers were included in the amoxicillin study and 28 individuals in the ampicillin study. Each study had an open randomized two-period crossover design and a 21-day washout period between phases. Plasma, saliva and gastric juice concentrations of amoxicillin and ampicillin in subjects with and without omeprazole pre-treatment were measured by reversed-phase HPLC using UV detection. Results:

Neither pre-treatment with omeprazole nor H. pylori infection interfered with the plasma bioavailability of amoxicillin or ampicillin, as assessed by the AUC_{0-2 h}. Neither ampicillin nor amoxicillin were detected in saliva or gastric juice in any study phase. Conclusion:

Short-term treatment with omeprazole does not interfere with the pharmacokinetics of amoxicillin or ampicillin. Our results also exclude the presence of a transfer mechanism for amoxicillin or ampicillin from the plasma to the gastric lumen.

Document Type: Research article

DOI: 10.1046/j.1365-2036.2002.01262.x

Affiliations: 1: Clinical Pharmacology and Gastroenterology Unit, São Francisco University Medical School, Bragança Paulista, SP, Brazil, 2: Department of Pathology, São Francisco University Medical School, Bragança Paulista, SP, Brazil, 3: Discipline of Gastroenterology, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Brazil

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Amoxicillin and ampicillin are not transferred to gastric juice irrespective of Helicobacter pylori status or acid blockade by omeprazole